INT202203

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTT1) cytoplasm (GSTT1)
Anatomy Link Frequency
blood 1
GSTT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 1 12.40 Low Low
alcohol 8 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Codeine 2 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
tramadol 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
antidepressant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Second Primary Neoplasms 1 98.28 Very High Very High Very High
Breast Cancer 17 87.60 High High
Cancer 25 86.16 High High
Immunotherapy Of Cancer 1 86.16 High High
Chromosome Aberrations 3 82.40 Quite High
Malignant Neoplastic Disease 2 80.96 Quite High
Hypersensitivity 10 78.52 Quite High
Multiple Chemical Sensitivity 20 74.76 Quite High
Obesity 16 68.88 Quite High
Disease 45 61.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, our analyses indicate that individual polymorphisms in GSTT1 and CYP2D6 genes were significant but minor predictors of blood trihalomethane levels 10 min after showering and of the differences between blood levels 10 min after showering and those at baseline.
Positive_regulation (polymorphisms) of GSTT1 in blood
1) Confidence 0.47 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199304 Disease Relevance 0.13 Pain Relevance 0
To our knowledge, one study assessed genetic polymorphisms and susceptibility to radiotherapy-related malignancies, but only evaluated GSTM1 and GSTT1, finding nonsignificant elevated risk for second cancers among those with gene deletions [26].
Positive_regulation (evaluated) of GSTT1 associated with second primary neoplasms
2) Confidence 0.47 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.54 Pain Relevance 0
Copy number variation: CYP2A6, CYP2D6, GSTM1, GSTT1 and 1500 other such sites
Positive_regulation (variation) of GSTT1
3) Confidence 0.25 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.17 Pain Relevance 0
Analysis of DNA adducts and cytogenetic endpoints have indicated an increased susceptibility of glutathione S-transferase M1 and/or T1 (GSTM1, GSTT1) null genotype to genotoxicity of common low-dose chemicals [7-9].
Positive_regulation (increased) of GSTT1
4) Confidence 0.20 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.42 Pain Relevance 0

General Comments

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