INT202239

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
liver 2
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 27 50.00 Quite Low
anesthesia 25 50.00 Quite Low
Infliximab 4 41.68 Quite Low
Inflammation 18 11.12 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
visual analogue scale 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 8 93.44 High High
Injury 5 92.48 High High
Syndrome 1 91.96 High High
Insulin Resistance 8 73.84 Quite High
Hypercalcemia 17 67.16 Quite High
Obesity 8 52.00 Quite High
Rheumatoid Arthritis 27 50.00 Quite Low
Hyperinsulinism 1 48.28 Quite Low
Body Weight 2 40.04 Quite Low
Necrosis 1 16.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A possible explanation for this unexpected increase in IGF-1 could be that glucocorticoids inhibit the production of IGF-1 in the muscle, followed by a decrease in negative feedback regulation of liver IGF-1, which would increase serum levels of IGF-1 [46].
Negative_regulation (decrease) of Negative_regulation (regulation) of IGF-1 in liver
1) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.23 Pain Relevance 0
Our study shows that amino acid infusion during surgery reduces the decrease in IGF-1.
Negative_regulation (reduces) of Negative_regulation (decrease) of IGF-1
2) Confidence 0.36 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.29 Pain Relevance 0

General Comments

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