INT202239

Context Info Confidence 0.39 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.53 Pain Relevance 0

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)

Anatomy Link Frequency liver 2 IGF1 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 27 50.00 anesthesia 25 50.00 Infliximab 4 41.68 Inflammation 18 11.12 cytokine 4 5.00 methotrexate 2 5.00 cINOD 1 5.00 Inflammatory marker 1 5.00 Pain 1 5.00 visual analogue scale 1 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 8 93.44 Injury 5 92.48 Syndrome 1 91.96 Insulin Resistance 8 73.84 Hypercalcemia 17 67.16 Obesity 8 52.00 Rheumatoid Arthritis 27 50.00 Hyperinsulinism 1 48.28 Body Weight 2 40.04 Necrosis 1 16.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A possible explanation for this unexpected increase in IGF-1 could be that glucocorticoids inhibit the production of IGF-1 in the muscle, followed by a decrease in negative feedback regulation of liver IGF-1, which would increase serum levels of IGF-1 [46].

Negative_regulation (decrease) of Negative_regulation (regulation) of IGF-1 in liver

1) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.23 Pain Relevance 0

Our study shows that amino acid infusion during surgery reduces the decrease in IGF-1.

Negative_regulation (reduces) of Negative_regulation (decrease) of IGF-1

2) Confidence 0.36 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.29 Pain Relevance 0

General Comments

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