INT202241

Context Info Confidence 0.48 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.56 Pain Relevance 0.82

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)

IGF1 (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 51 99.52 imagery 10 84.32 rheumatoid arthritis 77 81.44 agonist 1 76.20 Dopamine 1 75.88 cytokine 18 56.08 antagonist 1 10.16 Inflammation 11 5.00 Somatostatin 5 5.00 Pain 4 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 20 99.76 Injury 10 99.28 Renal Disease 6 90.08 Cancer 18 86.28 Rheumatoid Arthritis 77 81.44 Obesity 22 74.88 Disease 12 74.60 Pituitary Cancer 6 69.20 Acromegaly 17 50.00 Insulin Resistance 12 47.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Despite reductions in IGF-1 levels to as low as 239 ng/ml after seven months, the lanreotide dose was increased initially to 90 mg every four weeks, and then to 120 mg every four weeks one month later.

Positive_regulation (increased) of Negative_regulation (reductions) of IGF-1

1) Confidence 0.48 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.41 Pain Relevance 0.15

Unpublished data35 demonstrated that patients receiving rhIGF1/IGFBP-3 at a dose equivalent to a daily dose of rhIGF1 of 200 ?

Positive_regulation (equivalent) of Negative_regulation (dose) of rhIGF1

2) Confidence 0.44 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.07 Pain Relevance 0

The aim of this pilot study was to investigate the effect of two regimes of amino acids infusion, before and during hysterectomy, on the surgery induced decrease in IGF-1 and "diabetes of injury" [30].

Positive_regulation (induced) of Negative_regulation (decrease) of IGF-1 associated with diabetes mellitus and injury

3) Confidence 0.39 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.29 Pain Relevance 0.21

Amino acid infusion during anesthesia attenuates the surgery induced decline in IGF-1 and diminishes the "diabetes of injury" Background

Positive_regulation (induced) of Negative_regulation (decline) of IGF-1 associated with anesthesia, diabetes mellitus and injury

4) Confidence 0.39 Published 2007 Journal Nutr Metab (Lond) Section Title Doc Link PMC1779788 Disease Relevance 0.20 Pain Relevance 0.30

IGFBP-3 stabilizes circulating IGF-I, and reductions in IGFBP-3 can contribute to a decrease in IGF-I levels (due to decreased stability of the complex).

Positive_regulation (contribute) of Negative_regulation (decrease) of IGF-I

5) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.58 Pain Relevance 0.16

General Comments

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