INT202241

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.56
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 51 99.52 Very High Very High Very High
imagery 10 84.32 Quite High
rheumatoid arthritis 77 81.44 Quite High
agonist 1 76.20 Quite High
Dopamine 1 75.88 Quite High
cytokine 18 56.08 Quite High
antagonist 1 10.16 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 20 99.76 Very High Very High Very High
Injury 10 99.28 Very High Very High Very High
Renal Disease 6 90.08 High High
Cancer 18 86.28 High High
Rheumatoid Arthritis 77 81.44 Quite High
Obesity 22 74.88 Quite High
Disease 12 74.60 Quite High
Pituitary Cancer 6 69.20 Quite High
Acromegaly 17 50.00 Quite Low
Insulin Resistance 12 47.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite reductions in IGF-1 levels to as low as 239 ng/ml after seven months, the lanreotide dose was increased initially to 90 mg every four weeks, and then to 120 mg every four weeks one month later.
Positive_regulation (increased) of Negative_regulation (reductions) of IGF-1
1) Confidence 0.48 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.41 Pain Relevance 0.15
Unpublished data35 demonstrated that patients receiving rhIGF1/IGFBP-3 at a dose equivalent to a daily dose of rhIGF1 of 200 ?
Positive_regulation (equivalent) of Negative_regulation (dose) of rhIGF1
2) Confidence 0.44 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.07 Pain Relevance 0
The aim of this pilot study was to investigate the effect of two regimes of amino acids infusion, before and during hysterectomy, on the surgery induced decrease in IGF-1 and "diabetes of injury" [30].


Positive_regulation (induced) of Negative_regulation (decrease) of IGF-1 associated with diabetes mellitus and injury
3) Confidence 0.39 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.29 Pain Relevance 0.21
Amino acid infusion during anesthesia attenuates the surgery induced decline in IGF-1 and diminishes the "diabetes of injury"

Background

Positive_regulation (induced) of Negative_regulation (decline) of IGF-1 associated with anesthesia, diabetes mellitus and injury
4) Confidence 0.39 Published 2007 Journal Nutr Metab (Lond) Section Title Doc Link PMC1779788 Disease Relevance 0.20 Pain Relevance 0.30
IGFBP-3 stabilizes circulating IGF-I, and reductions in IGFBP-3 can contribute to a decrease in IGF-I levels (due to decreased stability of the complex).
Positive_regulation (contribute) of Negative_regulation (decrease) of IGF-I
5) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.58 Pain Relevance 0.16

General Comments

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