INT202254

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.23
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (COMT, DRD2) pigmentation (DRD2) cytosol (COMT)
mitochondrion (COMT) small molecule metabolic process (COMT) signal transducer activity (DRD2)
COMT (Homo sapiens)
DRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 116 100.00 Very High Very High Very High
Dopamine 12 100.00 Very High Very High Very High
fluoxetine 8 74.08 Quite High
Nortriptyline 8 72.96 Quite High
depression 28 64.40 Quite High
dopamine receptor 4 59.04 Quite High
alcohol 4 53.92 Quite High
addiction 4 52.64 Quite High
Disease Link Frequency Relevance Heat
Depression 40 64.40 Quite High
Manic Depressive Disorder 4 59.36 Quite High
Schizophrenia 4 56.72 Quite High
Drug Dependence 4 53.04 Quite High
Severe Combined Immunodeficiency 16 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Personality Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was recently reported that an interaction of the dopamine D2 receptor (DRD2) and catechol-O-methyltransferase (COMT) influences the behavioural approach system – as measured using Carver and White's Behavioural Inhibition and Behavioural Approach System (BIS/BAS) scales – in a sample of healthy German subjects.
catechol-O-methyltransferase Binding (interaction) of DRD2 associated with catechol-o-methyltransferase and dopamine
1) Confidence 0.41 Published 2007 Journal Behav Brain Funct Section Abstract Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.18
This paper reports our finding that DRD2 and COMT are not associated with behavioural activation in two independent Caucasian samples of depressed patients assessed with Cloninger's Temperament and Character Inventory (TCI) [13].


COMT Binding (associated) of DRD2 associated with catechol-o-methyltransferase
2) Confidence 0.41 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0.23 Pain Relevance 0.31
Reuter et al. [1] recently reported that the dopamine D2 receptor (DRD2) and catechol-O-methyltransferase (COMT) genes are associated with variation in individuals' behavioural approach system.
COMT Binding (associated) of DRD2 associated with catechol-o-methyltransferase and dopamine
3) Confidence 0.41 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.20
This study aimed to examine support for an association of DRD2 and COMT with behavioural activation, using the TCI within two independent samples of depressed outpatients (for both samples n = 146).


COMT Spec (examine) Binding (association) of DRD2 associated with catechol-o-methyltransferase
4) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Abstract Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.17

General Comments

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