INT202257

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.13
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT)
plasma membrane (COMT) cytoplasm (COMT)
COMT (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 302 100.00 Very High Very High Very High
Face pain 2 99.52 Very High Very High Very High
Pain 68 98.08 Very High Very High Very High
Catecholamine 16 97.24 Very High Very High Very High
Central nervous system 7 94.36 High High
medulla 1 93.32 High High
Dopamine 19 82.24 Quite High
IPN 6 80.64 Quite High
Neurotransmitter 5 79.44 Quite High
allodynia 3 74.00 Quite High
Disease Link Frequency Relevance Heat
Facial Pain 2 99.52 Very High Very High Very High
Pain 64 98.08 Very High Very High Very High
Chronic Fatigue Syndrome 80 89.24 High High
Inflammatory Pain 6 80.64 Quite High
Neuropathic Pain 5 74.00 Quite High
Fibromyalgia 40 73.44 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 22 71.20 Quite High
Attention Deficit Hyperactivity Disorder 4 64.08 Quite High
Disease Susceptibility 10 57.12 Quite High
Infection 7 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No significant association of gender with genotype or allele frequency of DRD2 and COMT was observed in either sample.
Localization (frequency) of COMT associated with catechol-o-methyltransferase
1) Confidence 0.75 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.27
The COMT gene is located in region 22q11.1 to 22q11.2 of chromosome 22.
Localization (located) of COMT gene associated with catechol-o-methyltransferase
2) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212567 Disease Relevance 0.66 Pain Relevance 0.88
Applying an exploratory cut-off of P < .10, significant interactions between the executive functioning domain deficit score and COMT were observed for number of sexual partners (?
Localization (observed) of COMT
3) Confidence 0.65 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0.07 Pain Relevance 0
SEAP was used to normalize COMT RNA abundance for transfection efficiency.
Localization (abundance) of COMT associated with catechol-o-methyltransferase
4) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0 Pain Relevance 0.21
Myofacial pain patients exhibit lower COMT activity relative to controls [7], and COMT inhibition increases pain sensitivity in rodents by promoting catecholamine stimulation of ?
Localization (relative) of COMT associated with pain, catechol-o-methyltransferase, catecholamine and face pain
5) Confidence 0.65 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.38 Pain Relevance 1.05
As shown in Table 2[18], there were ten candidate genes including COMT, corticotropin releasing hormone receptor 1 (CRHR1), corticotropin releasing hormone receptor 2 (CRHR2), MAOA, MAOB, NR3C1, POMC, solute carrier family 6 member 4 (SLC6A4), tyrosine hydroxylase (TH), and TPH2 genes.
Localization (releasing) of COMT associated with catechol-o-methyltransferase
6) Confidence 0.61 Published 2009 Journal J Transl Med Section Body Doc Link PMC2765429 Disease Relevance 0.51 Pain Relevance 0.12
As shown in Table 2[18], there were ten candidate genes including COMT, corticotropin releasing hormone receptor 1 (CRHR1), corticotropin releasing hormone receptor 2 (CRHR2), MAOA, MAOB, NR3C1, POMC, solute carrier family 6 member 4 (SLC6A4), tyrosine hydroxylase (TH), and TPH2 genes.
Localization (releasing) of COMT associated with catechol-o-methyltransferase
7) Confidence 0.61 Published 2009 Journal J Transl Med Section Body Doc Link PMC2765429 Disease Relevance 0.51 Pain Relevance 0.12

General Comments

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