INT202259

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.13
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Anatomy Link Frequency
pituitary 2
lactotrope 1
Pttg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 28 97.08 Very High Very High Very High
Dopamine 120 96.72 Very High Very High Very High
dopamine receptor 8 44.16 Quite Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prolactinoma 168 99.96 Very High Very High Very High
Hyperplasia 44 98.60 Very High Very High Very High
Targeted Disruption 88 97.64 Very High Very High Very High
Adenoma 12 97.48 Very High Very High Very High
Galactorrhea 24 90.40 High High
Hypertrophy 4 69.80 Quite High
Lymphatic System Cancer 4 51.52 Quite High
Leukemia 12 50.96 Quite High
Carcinoma 4 47.24 Quite Low
Cancer 92 46.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When compared to female wild-type mice, pituitaries from female D2R knockout mice had decreased PTTG concentration (normalized to actin content, Figure 1A, P = 0.00057), while no differences in pttg mRNA expression were found (normalized to the housekeeping gene GAPDH, Figure 1B).
Transcription (expression) of pttg associated with targeted disruption
1) Confidence 0.34 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.12 Pain Relevance 0.16
When pituitary pttg mRNA expression was analyzed in these macroprolactinomas, comparing resistant adenomas with those responding to dopaminergic pharmacological treatment, no differences were found (Figure 3B).


Spec (analyzed) Transcription (expression) of pttg in pituitary associated with adenoma and prolactinoma
2) Confidence 0.34 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.03 Pain Relevance 0.09
PTTG protein and mRNA expression were determined in the lactotrope hyperplasia of the D2R female knockout mouse.
Transcription (expression) of PTTG in lactotrope associated with targeted disruption and hyperplasia
3) Confidence 0.29 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.14 Pain Relevance 0.21
When pituitary pttg mRNA level was analyzed in these macroprolactinomas, no differences were found.
Spec (analyzed) Transcription (level) of pttg in pituitary associated with prolactinoma
4) Confidence 0.25 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1779802 Disease Relevance 0.84 Pain Relevance 0.07

General Comments

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