INT202268

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.10
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Anatomy Link Frequency
pituitary 4
lactotrope 2
Pttg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 15 97.40 Very High Very High Very High
Dopamine 61 97.08 Very High Very High Very High
metalloproteinase 1 53.04 Quite High
imagery 6 5.00 Very Low Very Low Very Low
dopamine receptor 4 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 60 99.44 Very High Very High Very High
Prolactinoma 85 99.36 Very High Very High Very High
Targeted Disruption 44 97.44 Very High Very High Very High
Hyperplasia 24 93.12 High High
Galactorrhea 12 89.36 High High
Apoptosis 11 89.28 High High
Hypertrophy 2 87.52 High High
Cancer 83 86.72 High High
Hypoxia 4 77.64 Quite High
Death 2 68.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, PTTG protein expression is sensitive to high estrogen levels, which decreases dopaminergic control of the lactotrope.
Regulation (sensitive) of Gene_expression (expression) of PTTG in lactotrope
1) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.30 Pain Relevance 0.18
In senescent rats no difference in pituitary PTTG protein expression was found when compared to young rats (Figure 2A).
Neg (no) Regulation (difference) of Gene_expression (expression) of PTTG in pituitary
2) Confidence 0.25 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.11 Pain Relevance 0.13
As a homolog of securine PTTG regulates the cell cycle and higher expression of PTTG was noted in pituitary adenomas.
Regulation (regulates) of Gene_expression (expression) of PTTG in pituitary associated with pituitary cancer
3) Confidence 0.19 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.68 Pain Relevance 0.03

General Comments

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