INT20227

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 1990
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.16
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lta) extracellular space (Lta) extracellular region (Lta)
Anatomy Link Frequency
liver 2
vasculature 1
spleens 1
heart 1
small intestine 1
Lta (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 9 100.00 Very High Very High Very High
qutenza 2 99.48 Very High Very High Very High
unmyelinated 1 97.88 Very High Very High Very High
Inflammation 150 96.28 Very High Very High Very High
Bile 84 86.28 High High
cva 7 75.92 Quite High
Dorsal horn 1 75.00 Quite High
depression 10 66.36 Quite High
anesthesia 11 58.68 Quite High
Inflammatory response 8 58.16 Quite High
Disease Link Frequency Relevance Heat
Cerebral Malaria 30 98.92 Very High Very High Very High
Necrosis 14 98.36 Very High Very High Very High
INFLAMMATION 158 96.28 Very High Very High Very High
Death 19 92.44 High High
Bacillus Anthracis Infection 28 90.56 High High
Cognitive Disorder 3 90.40 High High
Sleep Initiation And Maintenance Disorders 8 87.52 High High
Sprains And Strains 25 87.28 High High
Apoptosis 40 82.20 Quite High
Shock 25 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and proposed endothelial cells, astrocytes or microglia as possible source [32], while Rae et al reported a 3–4-fold up-regulation of LT mRNA in the brain of mice with CM [33].
Regulation (regulation) of LT mRNA in microglia associated with cerebral malaria
1) Confidence 0.35 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0.46 Pain Relevance 0.07
The LT-DRP was unaffected by neonatal capsaicin treatment that destroyed most unmyelinated fibers.
Neg (unaffected) Regulation (unaffected) of LT associated with qutenza and unmyelinated
2) Confidence 0.26 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9307119 Disease Relevance 0.07 Pain Relevance 0.19
Since several oxygen and hydroxyl radical scavengers and the cyclooxygenase inhibitor, meclofenamate sodium, did not inhibit protein extravasation, the findings support a role for LT as a mediator of cold-induced changes in BBB permeability in rats and guinea pigs and suggest that the inhibitory effects of phenidone on BBB permeability may be due to inhibition of LT production.
Regulation (role) of LT
3) Confidence 0.23 Published 1990 Journal J. Neurotrauma Section Abstract Doc Link 2127946 Disease Relevance 0.37 Pain Relevance 0.05
LTA immunoreactivity was detectable in the small intestine of all TCR??
Regulation (immunoreactivity) of LTA in small intestine
4) Confidence 0.23 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.74 Pain Relevance 0.36
LTA immunoreactivity was detectable in the spleens of all TCR??
Regulation (immunoreactivity) of LTA in spleens
5) Confidence 0.23 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.65 Pain Relevance 0.26
LTA immunoreactivity was not detectable in 3 of 3 wild-type (C57BL/6J) mice liver (Figure 1g).


Regulation (immunoreactivity) of LTA in liver
6) Confidence 0.23 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.29 Pain Relevance 0.19
LTA immunoreactivity was detectable in the livers of 5 of 13 (38.4%) TCR??
Regulation (immunoreactivity) of LTA in livers
7) Confidence 0.23 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.08 Pain Relevance 0.13
The data presented here provides the first direct evidence of profound LT-mediated effects on the heart and specifically on cardiac vasculature, presenting this organ as a key early target for LT function.
Regulation (target) of LT in vasculature
8) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 1.13 Pain Relevance 0.06
We report the heart as an early target of LT in mice and discuss a protective role for nNOS against LT-mediated cardiac damage.


Regulation (target) of LT in heart
9) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2680977 Disease Relevance 0.91 Pain Relevance 0.04
These data indicate that, in the absence of the genes encoding for TNF and LT-alpha, APAP bioactivation was not altered and mice still developed severe hepatic necrosis.
Neg (not) Regulation (altered) of LT-alpha associated with necrosis and paracetamol
10) Confidence 0.11 Published 1998 Journal Hepatology Section Abstract Doc Link 9537442 Disease Relevance 0.78 Pain Relevance 0.54
The values of LT-SRSL were significantly associated with the use of antihypertensive drugs, decreased GAF scale of DSM-IV Axis V, and decreased daily light exposure in multiple linear regression analyses intended to emphasize the major correlates.
Regulation (values) of LT-SRSL
11) Confidence 0.00 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2694625 Disease Relevance 0.68 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox