INT20228

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Context Info
Confidence 0.22
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.81
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lta) extracellular space (Lta) extracellular region (Lta)
Lta (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 99.20 Very High Very High Very High
tolerance 1 96.56 Very High Very High Very High
cINOD 12 95.40 Very High Very High Very High
cytokine 2 90.00 High High
Inflammatory mediators 1 88.52 High High
Multiple sclerosis 1 84.56 Quite High
aspirin 7 67.60 Quite High
COX-2 inhibitor 1 57.44 Quite High
nud 6 47.80 Quite Low
Antihistamine 1 32.88 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 15 99.20 Very High Very High Very High
Asthma 13 98.92 Very High Very High Very High
Bacterial Respiratory Disease 30 97.84 Very High Very High Very High
Disease 8 96.36 Very High Very High Very High
Vibrio Infection 12 87.60 High High
Demyelinating Disease 1 84.56 Quite High
Toxicity 5 83.68 Quite High
Urticaria 61 82.08 Quite High
Wheal 1 79.20 Quite High
Carcinoma 14 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since several oxygen and hydroxyl radical scavengers and the cyclooxygenase inhibitor, meclofenamate sodium, did not inhibit protein extravasation, the findings support a role for LT as a mediator of cold-induced changes in BBB permeability in rats and guinea pigs and suggest that the inhibitory effects of phenidone on BBB permeability may be due to inhibition of LT production.
Negative_regulation (inhibition) of Gene_expression (production) of LT
1) Confidence 0.22 Published 1990 Journal J. Neurotrauma Section Abstract Doc Link 2127946 Disease Relevance 0.35 Pain Relevance 0.04
The effect of the decoction/quercetin on production of these toxins was compared with that of 2-mercaptoethanol since thiols such as 2-mercaptoethanol, L-cysteine monohydrochloride and sodium thioglycolate have been reported to inhibit production of LT, CT and ST [30,31].
Negative_regulation (inhibit) of Gene_expression (production) of LT
2) Confidence 0.16 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2911405 Disease Relevance 0.17 Pain Relevance 0
It decreased production of both LT and CT and their binding to GM1.
Negative_regulation (decreased) of Gene_expression (production) of LT
3) Confidence 0.16 Published 2010 Journal BMC Complement Altern Med Section Abstract Doc Link PMC2911405 Disease Relevance 0.51 Pain Relevance 0
Similarly, the decrease in production of LT without arresting the growth of E. coli B831-2 is suggestive of P. guajava also being able to affect bacterial metabolism.
Negative_regulation (decrease) of Gene_expression (production) of LT
4) Confidence 0.16 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2911405 Disease Relevance 0.43 Pain Relevance 0.04
SV40-LT expression was detected almost always also in cells strongly expressing vimentin (Figure 2J).
Negative_regulation (detected) of Gene_expression (expression) of LT
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.08 Pain Relevance 0
Drugs that inhibit the synthesis of LT have clinical efficacy in asthma (6, 7).
Negative_regulation (inhibit) of Gene_expression (synthesis) of LT associated with asthma
6) Confidence 0.07 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779320 Disease Relevance 1.42 Pain Relevance 0.28
The inhibition of the LT synthesis increases the anti-inflammatory efficacy (especially in pneumological and rheumatological diseases), reducing the risk of gastric damage.
Negative_regulation (inhibition) of Gene_expression (synthesis) of LT associated with inflammation and disease
7) Confidence 0.05 Published 2004 Journal Arch Gerontol Geriatr Section Abstract Doc Link 15066307 Disease Relevance 0.68 Pain Relevance 0.50
The production of IL-1beta, IL-6, IFN-gamma, TNF-alpha and TNF-beta markedly decreased during 24-48 h after each injection, with limited dose-dependency and no evidence of tolerance or effect augmentation over 1 month.
Negative_regulation (decreased) of Gene_expression (production) of TNF-beta associated with tolerance
8) Confidence 0.04 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10496186 Disease Relevance 0.17 Pain Relevance 0.17

General Comments

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