INT20229

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Context Info
Confidence 0.23
First Reported 1987
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
brain 2
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 1 99.54 Very High Very High Very High
Inflammation 3 96.96 Very High Very High Very High
agonist 1 89.72 High High
Arthritis 1 63.76 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 96.96 Very High Very High Very High
Injury 1 96.68 Very High Very High Very High
Frostbite 3 93.64 High High
Pressure And Volume Under Development 3 65.28 Quite High
Experimental Arthritis 1 64.48 Quite High
Otitis 1 51.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Guanabenz, but not clonidine, B-HT 920 or B-HT 933 inhibited zymosan-induced LTC4 (IC50 = 13 microM) and PGE2 (IC50 = 10.9 microM) synthesis with no concomitant reduction in zymosan phagocytosis or cell viability.
Negative_regulation (inhibited) of Positive_regulation (zymosan-induced) of LTC4 associated with clonidine
1) Confidence 0.23 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3121363 Disease Relevance 0.44 Pain Relevance 0.25
In guinea pigs, the LT synthesis inhibitor phenidone (30 mg/kg, i.p.) completely blocked cold-induced LTC4 in brain.
Negative_regulation (blocked) of Positive_regulation (induced) of LTC4 in brain
2) Confidence 0.04 Published 1990 Journal J. Neurotrauma Section Abstract Doc Link 2127946 Disease Relevance 0.42 Pain Relevance 0.04

General Comments

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