INT20230

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Context Info
Confidence 0.56
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 12.44
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) extracellular space (Alb) extracellular region (Alb)
enzyme binding (Alb) DNA binding (Alb) protein complex (Alb)
Anatomy Link Frequency
plasma 8
joint 2
amygdala 2
urine 2
Alb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 7 100.00 Very High Very High Very High
methadone 6 100.00 Very High Very High Very High
amygdala 116 99.98 Very High Very High Very High
Inflammation 27 99.30 Very High Very High Very High
isoflurane 3 99.14 Very High Very High Very High
nMDA receptor 24 99.08 Very High Very High Very High
Analgesic 1 98.80 Very High Very High Very High
Central grey 174 96.84 Very High Very High Very High
methotrexate 7 96.84 Very High Very High Very High
Arthritis 27 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 208 100.00 Very High Very High Very High
Burns 20 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 4 100.00 Very High Very High Very High
Acute-phase Reaction 7 99.66 Very High Very High Very High
Diabetes Mellitus 56 99.56 Very High Very High Very High
INFLAMMATION 30 99.30 Very High Very High Very High
Arthritis 54 99.12 Very High Very High Very High
Pressure And Volume Under Development 38 97.78 Very High Very High Very High
Urological Neuroanatomy 190 96.84 Very High Very High Very High
Arthralgia 2 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increases in urinary albumin and protein after eight weeks of treatment were significantly inhibited by prolonged treatment with PPE.
Negative_regulation (inhibited) of Positive_regulation (increases) of albumin
1) Confidence 0.56 Published 2008 Journal Ren Fail Section Abstract Doc Link 18350451 Disease Relevance 1.78 Pain Relevance 0.11
Inhibition of aortic histamine synthesis by alpha-hydrazinohistidine inhibits increased aortic albumin accumulation in experimental diabetes in the rat.
Negative_regulation (inhibits) of Positive_regulation (accumulation) of aortic albumin associated with diabetes mellitus
2) Confidence 0.51 Published 1985 Journal Diabetologia Section Title Doc Link 4018454 Disease Relevance 0.62 Pain Relevance 0.09
The inhibitory effect of naloxone, methadone, or naloxone plus methadone on albumin accumulation in the culture medium was greater than the drug-induced reduction of protein synthesis.
Negative_regulation (effect) of Positive_regulation (accumulation) of albumin associated with narcan and methadone
3) Confidence 0.43 Published 1984 Journal Exp. Cell Biol. Section Abstract Doc Link 6489584 Disease Relevance 0.34 Pain Relevance 1.12
Topical local anaesthetics are potent inhibitors of burn-induced plasma albumin extravasation, probably by direct action on vascular permeability and by inhibition of various steps of the pathophysiological response after burn injury.
Negative_regulation (inhibitors) of Positive_regulation (burn-induced) of albumin in plasma associated with burns and injury
4) Confidence 0.43 Published 1998 Journal Burns Section Abstract Doc Link 9688195 Disease Relevance 1.38 Pain Relevance 0.08
Reduction of joint pains as well as increase of mobility and decrease of swelling of several joints were observed. the clinical signs of reduced inflammation were accompanied biochemically by reduction of serum immunoglobulins and an increase of serum albumin.
Negative_regulation (reduction) of Positive_regulation (increase) of serum albumin in joint associated with pressure and volume under development, arthralgia and inflammation
5) Confidence 0.41 Published 1980 Journal Br. J. Dermatol. Section Abstract Doc Link 7002197 Disease Relevance 0.72 Pain Relevance 0.27
The inhibition of the acute phase response was measured by reduction of high plasma Fn levels (42-79% decrease) and CRP levels (57-100% decrease) as well as elevation of subnormal levels of plasma albumin (57-101% increase) and iron (40-114% increase).
Negative_regulation (reduction) of Positive_regulation (elevation) of plasma albumin in plasma associated with acute-phase reaction
6) Confidence 0.32 Published 1988 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 3143680 Disease Relevance 1.37 Pain Relevance 0.70
In the present study there was a significant decrease in albumin level and increase in globulin level in arthritic rats.
Negative_regulation (decrease) of Positive_regulation (increase) of albumin associated with arthritis
7) Confidence 0.24 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2978115 Disease Relevance 1.02 Pain Relevance 0.16
MA was defined as the urine albumin to creatinine (ACR) ratio of < 300 mg/g (34 mg/mmol) creatinine, ?
Negative_regulation (defined) of Positive_regulation (urine) of albumin in urine
8) Confidence 0.23 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698093 Disease Relevance 0.41 Pain Relevance 0.05
the amygdala prevents predator stress-induced increases in ALB [26].
Negative_regulation (prevents) of Positive_regulation (increases) of ALB in amygdala associated with stress and amygdala
9) Confidence 0.18 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.32 Pain Relevance 0.52
stress blocks increases in ALB and
Negative_regulation (blocks) of Positive_regulation (increases) of ALB associated with stress
10) Confidence 0.18 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.39 Pain Relevance 0.70
Phenidone (30 and 100 mg/kg) also inhibited cerebral tissue accumulation of 125I-albumin and dye in rats and guinea pigs.
Negative_regulation (inhibited) of Positive_regulation (accumulation) of albumin
11) Confidence 0.12 Published 1990 Journal J. Neurotrauma Section Abstract Doc Link 2127946 Disease Relevance 0.42 Pain Relevance 0.04
Argani and colleagues showed a decrease in plasma levels of triglyceride (TG) and very low-density lipoprotein, and increases in total high-density lipoprotein cholesterol (HDL-C and HDL2-C) and albumin, in hemodialysis patients upon administration of 500 mg/day carnitine taken orally for 2 months [44].


Negative_regulation (decrease) of Positive_regulation (increases) of albumin in plasma associated with disorder of lipid metabolism
12) Confidence 0.10 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2861661 Disease Relevance 0.51 Pain Relevance 0
In addition, the rate constant for equilibration between plasma concentration and effect decreased 46% per 1% increase in isoflurane, central compartment volume decreased 86% per 1% increase in isoflurane concentration, and slow distributional Cl decreased 69% per mg/ 100 mL increase in serum albumin.
Negative_regulation (decreased) of Positive_regulation (increase) of albumin in plasma associated with isoflurane
13) Confidence 0.09 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10475326 Disease Relevance 0.72 Pain Relevance 0.20
The levels of albumin mRNA and transthyretin mRNA (also called prealbumin) decreased to about 80% of normal and the level of transferrin mRNA did not change significantly.
Negative_regulation (decreased) of Positive_regulation (called) of albumin mRNA
14) Confidence 0.08 Published 1987 Journal J Trauma Section Abstract Doc Link 2435922 Disease Relevance 0.23 Pain Relevance 0.08
All analitic parameters studied, clearly improved after embolization with decrease of ferritin and CRP, increase of albumin and better hemoglobin level with lower erythropoietin dose.
Negative_regulation (decrease) of Positive_regulation (increase) of albumin
15) Confidence 0.04 Published 2005 Journal Nefrologia Section Body Doc Link 16231510 Disease Relevance 0.20 Pain Relevance 0

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