INT202309

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.92
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDGFB) cytoplasm (PDGFB)
Anatomy Link Frequency
fibroblasts 2
PDGFB (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 17 100.00 Very High Very High Very High
Inflammation 18 92.60 High High
isoflurane 4 86.72 High High
anesthesia 4 85.84 High High
dexamethasone 1 82.84 Quite High
chemokine 108 80.96 Quite High
fibrosis 17 40.64 Quite Low
Inflammatory response 1 21.68 Low Low
Glutamate 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wound Healing 8 95.84 Very High Very High Very High
Injury 12 94.56 High High
Fibrosis 19 92.96 High High
INFLAMMATION 20 92.60 High High
Bronchopulmonary Dysplasia 1 89.16 High High
Disease 8 79.28 Quite High
Pulmonary Fibrosis 8 40.64 Quite Low
Radiation Sickness 2 27.68 Quite Low
Cancer 46 26.16 Quite Low
Glioma 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By controlling the MW of the MS over a range of 6.5 KDa┬ľ64 KDa, release rates of PDGF can be regulated over periods of weeks to months in vitro.
Regulation (regulated) of Localization (release) of PDGF
1) Confidence 0.36 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2248711 Disease Relevance 0.16 Pain Relevance 0.04
These results indicate that tissue penetration and specimen area are dependent on in vivo PDGF release rate.
Regulation (dependent) of Localization (release) of PDGF
2) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0.10
However, a major obstacle for its successful clinical application is the delivery system, which ultimately controls the in vivo release rate of PDGF.
Regulation (controls) of Localization (release) of PDGF
3) Confidence 0.26 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2248711 Disease Relevance 0.09 Pain Relevance 0.04
Thus, stromal cells, such as endothelial, fibroblasts cells, should be at least partially responsible for the release of cytokines, including PDGF.
Spec (partially) Regulation (responsible) of Localization (release) of PDGF in fibroblasts associated with cytokine
4) Confidence 0.24 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.57 Pain Relevance 0.18
In order to investigate the effect of PDGF release rate on PDGF biological function in vivo, nine groups of 3 animals each were prepared to test in a rat wound healing model. [24] They were grouped as follows:
Spec (investigate) Regulation (effect) of Spec (investigate) Localization (release) of PDGF associated with wound healing
5) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.10 Pain Relevance 0.13

General Comments

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