INT202313

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.00
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PDGFB, Pdgfrb) signal transduction (Pdgfrb) extracellular region (PDGFB)
plasma membrane (Pdgfrb) nucleus (Pdgfrb) kinase activity (Pdgfrb)
Anatomy Link Frequency
lungs 3
PDGFB (Homo sapiens)
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 17 83.36 Quite High
Inflammatory response 1 73.84 Quite High
cytokine 9 48.56 Quite Low
Inflammation 6 48.16 Quite Low
cINOD 1 29.08 Quite Low
antagonist 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 19 98.52 Very High Very High Very High
Pulmonary Fibrosis 8 83.84 Quite High
INFLAMMATION 8 73.84 Quite High
Radiation Sickness 2 71.20 Quite High
Pneumonia 3 51.16 Quite High
Disease 4 47.76 Quite Low
Necrosis 1 43.72 Quite Low
Cancer 42 43.36 Quite Low
Lung Cancer 2 5.28 Low Low
Glioma 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The radiation-induced overexpression of PDGF led to phosphorylation and activation of PDGFR in lungs of irradiated mice, while the phosphorylation of PDGFR was strongly inhibited in both irradiated groups treated with RTKIs.
Gene_expression (overexpression) of PDGF in lungs Positive_regulation (led) of Positive_regulation (activation) of PDGFR in lungs
1) Confidence 0.14 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.00 Pain Relevance 0.29

General Comments

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