INT20233

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Context Info
Confidence 0.51
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 4.19
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SMPD1) extracellular space (SMPD1) small molecule metabolic process (SMPD1)
hydrolase activity, acting on glycosyl bonds (SMPD1) cell death (SMPD1)
Anatomy Link Frequency
liver 2
fibroblasts 2
brain 1
SMPD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 7 92.64 High High
Inflammation 102 92.00 High High
cINOD 3 87.68 High High
anesthesia 7 87.08 High High
antagonist 10 84.44 Quite High
agonist 60 81.68 Quite High
metalloproteinase 3 79.52 Quite High
corticosteroid 1 78.76 Quite High
Spinal cord 3 77.24 Quite High
chemokine 30 70.68 Quite High
Disease Link Frequency Relevance Heat
Hypertrophy 6 94.12 High High
INFLAMMATION 123 92.00 High High
Lysosomal Storage Diseases 7 91.72 High High
Sphingolipidoses 6 90.40 High High
Asthma 89 87.12 High High
Pick Disease Of The Brain 8 87.04 High High
Airway Remodeling 15 86.48 High High
Lipidosis 6 86.16 High High
Disease 24 85.20 High High
Neuroaxonal Dystrophies 3 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cultured skin fibroblasts had partially decreased sphingomyelinase activity and a greatly decreased ability to esterify exogenous cholesterol.
Negative_regulation (decreased) of sphingomyelinase in fibroblasts
1) Confidence 0.51 Published 1990 Journal Acta Neuropathol. Section Abstract Doc Link 2127982 Disease Relevance 0.54 Pain Relevance 0.10
Sphingomyelinase activity in liver was partially deficient or low normal.
Spec (partially) Negative_regulation (deficient) of Sphingomyelinase in liver
2) Confidence 0.43 Published 1990 Journal Acta Neuropathol. Section Abstract Doc Link 2127982 Disease Relevance 0.51 Pain Relevance 0.11
The cultured skin fibroblasts had partially decreased sphingomyelinase activity and a greatly decreased ability to esterify exogenous cholesterol.
Negative_regulation (decreased) of sphingomyelinase in fibroblasts
3) Confidence 0.37 Published 1990 Journal Acta Neuropathol. Section Abstract Doc Link 2127982 Disease Relevance 0.55 Pain Relevance 0.10
Sphingomyelinase activity measured with 14C labeled sphingomyelin at pH 5.0 was virtually absent in brain and liver.
Negative_regulation (absent) of Sphingomyelinase in liver
4) Confidence 0.30 Published 1987 Journal Vet. Pathol. Section Abstract Doc Link 3672804 Disease Relevance 0.51 Pain Relevance 0.09
SMPD1 was down-regulated in DH animals in the microarray study, but we were not able to confirm this in the rcPCR analyses.
Negative_regulation (down-regulated) of SMPD1
5) Confidence 0.19 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2204014 Disease Relevance 0.13 Pain Relevance 0
Sphingomyelinase activity measured with 14C labeled sphingomyelin at pH 5.0 was virtually absent in brain and liver.
Negative_regulation (absent) of Sphingomyelinase in brain
6) Confidence 0.10 Published 1987 Journal Vet. Pathol. Section Abstract Doc Link 3672804 Disease Relevance 0.51 Pain Relevance 0.09
Therefore, by reducing the amount of ASM in the airway wall this technique reduces the ability of the airway to contract.
Negative_regulation (reducing) of ASM
7) Confidence 0.08 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC3006421 Disease Relevance 0.09 Pain Relevance 0
Beclomethasone and cortisol were also found to inhibit bovine ASM cell proliferation in culture [64].
Negative_regulation (inhibit) of ASM
8) Confidence 0.07 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.28 Pain Relevance 0.86
A diagram of Gq-coupled receptor signaling, and the associated functional outcomes in ASM, is provided in Fig. 1.
Negative_regulation (provided) of ASM
9) Confidence 0.06 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.07 Pain Relevance 0.07

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