INT20234

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Context Info
Confidence 0.44
First Reported 1990
Last Reported 2007
Negated 1
Speculated 6
Reported most in Abstract
Documents 11
Total Number 16
Disease Relevance 6.55
Pain Relevance 7.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
spinal 4
spinal cord 2
PGE2 2
kidney 2
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 13 100.00 Very High Very High Very High
cOX1 7 100.00 Very High Very High Very High
COX2 7 100.00 Very High Very High Very High
Spinal nerve ligature 6 100.00 Very High Very High Very High
nociceptor 1 100.00 Very High Very High Very High
cINOD 16 99.84 Very High Very High Very High
Hyperalgesia 8 99.82 Very High Very High Very High
Inflammation 21 99.72 Very High Very High Very High
Thermal hyperalgesia 8 99.12 Very High Very High Very High
antinociception 2 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 25 99.90 Very High Very High Very High
Hyperalgesia 20 99.82 Very High Very High Very High
Injury 7 99.62 Very High Very High Very High
Pressure And Volume Under Development 5 99.48 Very High Very High Very High
Nociception 8 98.72 Very High Very High Very High
Neuropathic Pain 11 98.48 Very High Very High Very High
Inflammatory Pain 2 98.36 Very High Very High Very High
Pain 5 98.12 Very High Very High Very High
Cv Unclassified Under Development 1 96.12 Very High Very High Very High
Nervous System Injury 6 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of cyclooxygenase products of arachidonic acid metabolism on cutaneous nociceptive threshold in the rat.
Regulation (Effects) of Gene_expression (products) of cyclooxygenase associated with nociception and nociceptor
1) Confidence 0.44 Published 1990 Journal Brain Res. Section Title Doc Link 2128200 Disease Relevance 0.61 Pain Relevance 0.59
In gastric mucosa the expression of the cyclooxygenase-1 was not affected and the expression of cyclooxygenase-2 was not observed.
Neg (not) Regulation (affected) of Gene_expression (expression) of cyclooxygenase-1
2) Confidence 0.43 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12498303 Disease Relevance 0.25 Pain Relevance 0.72
In the present study, we examined the changes of cyclooxygenase-1 and cyclooxygenase-2 protein expression in several regions of the CNS associated with pain perception, and the role of spinal cyclooxygenase activity in the development of allodynia following nerve injury.
Spec (examined) Regulation (changes) of Gene_expression (expression) of cyclooxygenase-1 in spinal associated with pain, nervous system injury and allodynia
3) Confidence 0.39 Published 2000 Journal Neuroscience Section Abstract Doc Link 10842019 Disease Relevance 0.72 Pain Relevance 0.54
In addition, the effects of these compounds on gene expression and protein production of the two isoforms of the cyclooxygenase (COX) gene which are responsible for prostaglandin production were examined.
Regulation (effects) of Gene_expression (production) of cyclooxygenase
4) Confidence 0.34 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10697514 Disease Relevance 0.23 Pain Relevance 0.10
Here, the authors investigated changes in the expression of cyclooxygenase and nitric oxide synthase (NOS) isoforms in the lumbar, thoracic, and cervical spinal cord and the pharmacologic sensitivity to spinal prostaglandin E2 (PGE2) after L5-L6 spinal nerve ligation (SNL).
Spec (investigated) Regulation (changes) of Gene_expression (expression) of cyclooxygenase in PGE2 associated with spinal nerve ligature and spinal cord
5) Confidence 0.25 Published 2006 Journal Anesthesiology Section Abstract Doc Link 16436853 Disease Relevance 0.10 Pain Relevance 0.35
Electroacupuncture inhibits inflammatory edema and hyperalgesia through regulation of cyclooxygenase synthesis in both peripheral and central nociceptive sites.
Regulation (regulation) of Gene_expression (synthesis) of cyclooxygenase associated with nociception, pressure and volume under development, hyperalgesia, inflammation and electroacupuncture
6) Confidence 0.24 Published 2006 Journal Am. J. Chin. Med. Section Title Doc Link 17163587 Disease Relevance 1.12 Pain Relevance 1.12
Effect of papillotoxic agents on expression of cyclooxygenase isoforms in the rat kidney.
Regulation (Effect) of Gene_expression (expression) of cyclooxygenase in kidney associated with cox1
7) Confidence 0.21 Published 1998 Journal Toxicol Pathol Section Title Doc Link 9502396 Disease Relevance 0.67 Pain Relevance 0.32
We have examined the role of peripheral prostaglandins synthesized by cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in inflammatory pain using the PIFIR model.
Spec (examined) Regulation (role) of Gene_expression (synthesized) of cyclooxygenase-1 associated with ipn
8) Confidence 0.19 Published 2002 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11902807 Disease Relevance 0.70 Pain Relevance 0.77
All-trans retinoic acid (ATRA), the active metabolite of vitamin A, is involved in the inflammatory reaction and modulates the expression of cyclooxygenase (COX) enzymes and nitric oxide (NO) activity.
Regulation (modulates) of Gene_expression (expression) of cyclooxygenase associated with inflammation
9) Confidence 0.17 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16870215 Disease Relevance 0.18 Pain Relevance 0.59
In addition, the effects of these compounds on gene expression and protein production of the two isoforms of the cyclooxygenase (COX) gene which are responsible for prostaglandin production were examined.
Regulation (effects) of Gene_expression (expression) of cyclooxygenase
10) Confidence 0.15 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10697514 Disease Relevance 0.23 Pain Relevance 0.10
AIM: To determine the role of the mucosal gene expression for spasmolitic peptide (SP) (a member of trefoil peptides) and transforming growth factor alpha (TGF alpha) as well as for cyclooxygenase (COX)-1 and COX-2 during gastric adaptation to ASA in rats.
Spec (determine) Regulation (role) of Spec (determine) Gene_expression (expression) of cyclooxygenase
11) Confidence 0.14 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9726391 Disease Relevance 0.09 Pain Relevance 0
In contrast, the expression of mRNA for cyclooxygenase-1 was constitutive and was never affected by NSAIDs.
Regulation (affected) of Gene_expression (expression) of cyclooxygenase-1 associated with cinod
12) Confidence 0.14 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9851595 Disease Relevance 0.44 Pain Relevance 0.60
Intrathecal administration of nonsteroidal anti-inflammatory drugs in the rat blocks the thermal hyperalgesia induced by tissue injury, which suggests a role for spinal cyclooxygenase (COX) products in this facilitated state.
Regulation (role) of Gene_expression (products) of cyclooxygenase in spinal associated with inflammation, thermal hyperalgesia, injury, cinod and intrathecal
13) Confidence 0.11 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618405 Disease Relevance 0.50 Pain Relevance 0.48
This study examined the effect of SNL on the expression of cyclooxygenase (COX)-1, COX-2, and prostaglandin E2 receptors in the rat lumbar spinal cord, and the temporal and pharmacologic relation of these changes to the exaggerated A- and C-fiber-mediated reflex responses and allodynia, 24 h after injury.
Spec (examined) Regulation (effect) of Gene_expression (expression) of cyclooxygenase in spinal cord associated with c fibre, allodynia, spinal nerve ligature, injury and spinal cord
14) Confidence 0.10 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17413918 Disease Relevance 0.36 Pain Relevance 0.85
This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation.
Spec (investigate) Regulation (effects) of Gene_expression (production) of cyclooxygenase associated with inflammation
15) Confidence 0.06 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15448533 Disease Relevance 0.37 Pain Relevance 0.23
Biochemical changes in prostanoids and cerebral expression of cyclooxygenase (COX)-1 and COX-2 during morphine sulfate infusion in the newborn piglet .
Regulation (changes) of Gene_expression (expression) of cyclooxygenase associated with cox1 and morphine
16) Confidence 0.01 Published 1999 Journal Prostaglandins Other Lipid Mediat. Section Title Doc Link 10593169 Disease Relevance 0 Pain Relevance 0.37

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