INT202344

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.08
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Map3k3)
Anatomy Link Frequency
morula 1
lung 1
Map3k3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 172 95.60 Very High Very High Very High
Inflammation 22 60.64 Quite High
cINOD 4 51.56 Quite High
cytokine 13 50.12 Quite High
agonist 9 50.00 Quite Low
metalloproteinase 3 25.00 Low Low
Opioid 28 5.00 Very Low Very Low Very Low
withdrawal 12 5.00 Very Low Very Low Very Low
Physical dependence 10 5.00 Very Low Very Low Very Low
Eae 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Injury 58 97.80 Very High Very High Very High
Neuroblastoma 4 97.72 Very High Very High Very High
Sprains And Strains 86 94.40 High High
Disease 96 89.84 High High
Congenital Anomalies 8 89.20 High High
Alzheimer's Dementia 5 85.44 High High
Stress 46 84.88 Quite High
Hypoxia 8 82.04 Quite High
Toxicity 3 65.24 Quite High
Targeted Disruption 1 63.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of OSM by RNA interference demonstrated that MAP3K3 and OSM were required for p38 MAPK activation in response to sorbitol-induced hypertonicity [26].
Positive_regulation (required) of MAP3K3
1) Confidence 0.49 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.14 Pain Relevance 0.08
Uhlik et al. reported a 2.01-fold increase in MEKK3 kinase activity in HEK293 cells treated with 0.2 M sorbitol for 15 minutes [26].
Positive_regulation (increase) of MEKK3
2) Confidence 0.49 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
The kinetics of hyperosmolarity-induced MAP3K3 activation reported in that study closely mirrored that of endogenous p38 MAPK activation in the HEK293 cells.
Positive_regulation (activation) of MAP3K3
3) Confidence 0.45 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Of particular note is the nearly 40-fold increase over 1-cell levels in Map3k3 expression at the morula stage, and the 12-fold increase over the same period in Map2k3 expression which indicates that MAP3K3 and MAP2K3 may be the primary upstream activators of p38 MAPK during preimplantation development.
Positive_regulation (activators) of MAP3K3 in morula
4) Confidence 0.45 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
We characterize the role of p38 mitogen-activated protein kinase/mitogen activated protein kinase kinase-3 and c-Jun-NH2-terminal kinase-1 in ventilator-induced lung injury and investigate novel independent mechanisms contributing to lung injury during mechanical ventilation.


Positive_regulation (activated) of protein kinase kinase-3 in lung associated with lung injury
5) Confidence 0.11 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2223071 Disease Relevance 0.76 Pain Relevance 0.03
Equal upregulation (about 1.5-fold to 2-fold) of mRNAs for serum/glucocorticoid regulated kinase 3 (Sgk3) and calcium/calmodulin-dependent protein kinase I gamma (Camk1g) was observed after acute and chronic morphine exposure in all four strains of mice.
Positive_regulation (upregulation) of kinase 3 associated with sprains and strains and morphine
6) Confidence 0.03 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.39 Pain Relevance 0.56
Calyculin A resulted in activation of glycogen synthase kinase 3 (GSK-3), a redox-controlled enzyme involved in various regulatory mechanisms of the cell, and the consequent hyperphosphorylation of tau [91].
Positive_regulation (activation) of kinase 3
7) Confidence 0.01 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.78 Pain Relevance 0

General Comments

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