INT202347

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.74
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 36
Disease Relevance 11.68
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k4) nucleus (Map2k4) kinase activity (Map2k4)
response to stress (Map2k4) cytoplasm (Map2k4)
Anatomy Link Frequency
retinas 8
neurons 3
B cells 2
nucleus 1
Map2k4 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 456 84.80 Quite High
cINOD 12 11.56 Low Low
cytokine 24 10.12 Low Low
Central nervous system 24 5.00 Very Low Very Low Very Low
ketamine 24 5.00 Very Low Very Low Very Low
anesthesia 24 5.00 Very Low Very Low Very Low
depression 12 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 648 99.70 Very High Very High Very High
Carcinoma 12 99.48 Very High Very High Very High
Death 432 99.20 Very High Very High Very High
Glaucoma 48 96.40 Very High Very High Very High
Diabetic Retinopathy 48 95.88 Very High Very High Very High
Cv Unclassified Under Development 432 84.80 Quite High
Congenital Anomalies 72 83.64 Quite High
Shock 36 79.72 Quite High
Ganglion Cysts 96 77.36 Quite High
Stroke 24 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MAP2K4 was detected in both the nucleus and cytoplasm of differentiated P19 cells, but only in the nucleus of undifferentiated P19 cells [28].
Gene_expression (detected) of MAP2K4 in nucleus
1) Confidence 0.74 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.18 Pain Relevance 0
Relative abundance of mRNAs encoding Ccm2, Map3k3, Map2k3, Map2k6, Map2k4 and Mapk14 during mouse preimplantation development
Gene_expression (encoding) of Map2k4
2) Confidence 0.64 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Pre-designed and pre-optimized commercially available TaqMan® Gene Expression Assays for MEKK3/Map3k3 (Assay ID: Mm00803725_m1), MKK3/Map2k3 (Assay ID: Mm00435950_m1), MKK6/Map2k6 (Assay ID: Mm00803694_m1), MKK4/Map2k4 (Assay ID: Mm00436508_m1), p38?
Gene_expression (/) of MKK4
3) Confidence 0.64 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Primer pairs were designed and synthesized (Sigma-Aldrich Canada Ltd., Oakville, ON, Canada) for Ccm2, Map3k3, Map2k3, Map2k6, Map2k4, and H2afz based on mouse nucleotide sequences in the Ensembl mouse transcript database.
Gene_expression (synthesized) of Map2k4
4) Confidence 0.64 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Cellular distribution of CCM2, MAP3K3, phosphorylated MAP2K3/MAP2K6 and phosphorylated MAP2K4 proteins during mouse preimplantation development
Gene_expression (proteins) of MAP2K4
5) Confidence 0.64 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Phosphorylated MAP2K3/MAP2K6 (Figure 3 p-MAP2K3/6 1-cell to blastocyst) and phosphorylated MAP2K4 (Figure 3 p-MAP2K4 1-cell to blastocyst) were also detected throughout preimplantation development.
Gene_expression (detected) of MAP2K4
6) Confidence 0.64 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Our results indicate that Ccm2 along with upstream p38 MAPK pathway constituents (Map3k3, Map2k3, Map2k6, and Map2k4) are expressed throughout mouse preimplantation development.
Gene_expression (expressed) of Map2k4
7) Confidence 0.58 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
In conclusion, we have demonstrated for the first time that transcripts and polypeptides encoding MAP3K3, MAP2K3, MAP2K6, MAP2K4 and CCM2 are expressed and localized throughout mouse preimplantation development.
Gene_expression (expressed) of MAP2K4
8) Confidence 0.58 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
MAP2K3, MAP2K6, and MAP2K4) are present throughout mouse preimplantation development.
Gene_expression (present) of MAP2K4
9) Confidence 0.58 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
CCM2, MAP3K3 and the phosphorylated forms of MAP2K3/MAP2K6 and MAP2K4 were also detected throughout preimplantation development.
Gene_expression (detected) of MAP2K4
10) Confidence 0.58 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
Qualitative RT-PCR methods resulted in the detection of mRNA transcripts encoding Ccm2, Map3k3, Map2k3, Map2k6 and Map2k4 producing the expected size amplicons of 371 bp, 374 bp, 387 bp, 395 bp and 363 bp respectively throughout mouse preimplantation development in all 3 experimental replicates (Figure 2A).
Gene_expression (producing) of Map2k4
11) Confidence 0.58 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
Pre-designed and pre-optimized commercially available TaqMan® Gene Expression Assays for MEKK3/Map3k3 (Assay ID: Mm00803725_m1), MKK3/Map2k3 (Assay ID: Mm00435950_m1), MKK6/Map2k6 (Assay ID: Mm00803694_m1), MKK4/Map2k4 (Assay ID: Mm00436508_m1), p38?
Gene_expression (/) of Map2k4
12) Confidence 0.28 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Semi-quantitative analysis of expression of ASK1, p-SEK1/MEK4, and p-JNK in the GCL
Gene_expression (expression) of MEK4
13) Confidence 0.18 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.15 Pain Relevance 0
Both ASK1 and SEK1/MEK4 expression in the GCL was significantly increased only at the initial phase after reperfusion.
Gene_expression (expression) of SEK1
14) Confidence 0.18 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.97 Pain Relevance 0
Both ASK1 and SEK1/MEK4 expression in the GCL was significantly increased only at the initial phase after reperfusion.
Gene_expression (expression) of MEK4
15) Confidence 0.18 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.91 Pain Relevance 0
Semi-quantitative analysis of expression of ASK1, p-SEK1/MEK4, and p-JNK in the GCL
Gene_expression (expression) of p-SEK1
16) Confidence 0.15 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.15 Pain Relevance 0
An increase of intracellular Ca2+ concentration can activate SEK1/MEK4 because SEK1/MEK4 is activated under transiently high concentrations of Ca2+ in B cells (Dolmetsch et al 1997).
Gene_expression (/) of SEK1 in B cells
17) Confidence 0.15 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.86 Pain Relevance 0
In addition, the numbers of ASK1-, p-SEK1/MEK4-, and p-JNK-positive cells that were double stained with Fluoro-Jade B were counted in the GCL.
Gene_expression (counted) of MEK4
18) Confidence 0.15 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.13 Pain Relevance 0
An increase of intracellular Ca2+ concentration can activate SEK1/MEK4 because SEK1/MEK4 is activated under transiently high concentrations of Ca2+ in B cells (Dolmetsch et al 1997).
Gene_expression (/) of MEK4 in B cells
19) Confidence 0.15 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.86 Pain Relevance 0
Semi-quantitative analysis of expression of ASK1, p-SEK1/MEK4, and p-JNK in the GCL
Gene_expression (analysis) of MEK4
20) Confidence 0.15 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox