INT202349

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.26
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Map2k3)
Anatomy Link Frequency
morula 1
Map2k3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 139 100.00 Very High Very High Very High
Inflammation 121 100.00 Very High Very High Very High
Inflammatory response 17 47.48 Quite Low
chemokine 27 45.24 Quite Low
Inflammatory mediators 24 41.04 Quite Low
bradykinin 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 157 100.00 Very High Very High Very High
Stress 11 100.00 Very High Very High Very High
Bacterial Meningitis 5 95.40 Very High Very High Very High
Otitis Media 134 91.88 High High
Communicable Diseases 6 87.40 High High
Bacterial Infection 4 65.80 Quite High
Apoptosis 7 64.72 Quite High
Sprains And Strains 120 54.80 Quite High
Infection 124 50.00 Quite Low
Shock 3 39.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Map2k3 is induced by various stimuli, including cellular stress, inflammatory cytokines and cell surface receptors, and mediates the activation of p38 mitogen-activated protein kinase (p38MAPK) [32].
Positive_regulation (induced) of Map2k3 associated with stress, inflammation and cytokine
1) Confidence 0.52 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.49 Pain Relevance 0.16
B translocation-independent pathway involves activation of the MKK3/6-p38 mitogen-activated protein kinase (MAPK) pathway (221).
Positive_regulation (activation) of MKK3
2) Confidence 0.49 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.21 Pain Relevance 0.03
Of particular note is the nearly 40-fold increase over 1-cell levels in Map3k3 expression at the morula stage, and the 12-fold increase over the same period in Map2k3 expression which indicates that MAP3K3 and MAP2K3 may be the primary upstream activators of p38 MAPK during preimplantation development.
Positive_regulation (activators) of MAP2K3 in morula
3) Confidence 0.45 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Map2k3 is induced by various stimuli, including cellular stress, inflammatory cytokines and cell surface receptors, and mediates the activation of p38 mitogen-activated protein kinase (p38MAPK) [32].
Positive_regulation (mediates) of Map2k3 associated with stress, inflammation and cytokine
4) Confidence 0.37 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.56 Pain Relevance 0.17

General Comments

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