INT202355

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.60
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mef2c) nucleus (Mef2c) DNA binding (Mef2c)
protein complex (Mef2c) cytoplasm (Mef2c)
Anatomy Link Frequency
myocardium 1
Mef2c (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 94.56 High High
cINOD 1 92.88 High High
imagery 4 53.68 Quite High
anesthesia 11 10.12 Low Low
fibrosis 30 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 32 97.20 Very High Very High Very High
INFLAMMATION 1 92.48 High High
Targeted Disruption 9 88.44 High High
Stress 32 79.28 Quite High
Adhesions 3 75.92 Quite High
Left Ventricular Hypertrophy 30 50.00 Quite Low
Hypertrophy 27 23.12 Low Low
Coronary Heart Disease 39 5.00 Very Low Very Low Very Low
Fibrosis 30 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myocardial MEF2A, MEF2C, MEF2D and ANP transcripts were quantified after reverse transcription to cDNA followed by real-time PCR.
Transcription (transcripts) of MEF2C
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0.03
Further analysis confirmed similar reductions in MEF2C transcripts in the myocardium over time after the administration of siMEF2C (Figure 3B).
Transcription (transcripts) of MEF2C in myocardium
2) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.08 Pain Relevance 0
Reduction in MEF2C transcripts and protein levels was also demonstrated to occur in banded mice treated with siMEF2C (Figure 2F, G).
Transcription (transcripts) of MEF2C
3) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
Downstream substrates of the p38 MAPKs include protein kinases such as MAPK-activated protein kinase 2 (MAPKAPK2) [18] and p38 regulated/activated kinase (PRAK/MAPKAPK5) [19], as well as several transcription factors including MEF2, CHOP, and ATF2 [10].
Transcription (transcription) of MEF2
4) Confidence 0.41 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.17 Pain Relevance 0.18
Lower relative expression of cardiomyogenic transcription factors, such as GATA-4, Nkx2-5, Isl-1, Mef2 and Hand2, was seen in clonal cell culture.
Transcription (transcription) of Mef2
5) Confidence 0.31 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2262151 Disease Relevance 0.36 Pain Relevance 0

General Comments

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