INT202357

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 1.94
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Map2k3)
Anatomy Link Frequency
morula 1
nucleus 1
Map2k3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 36 85.64 High High
cytokine 32 49.88 Quite Low
cINOD 12 12.32 Low Low
imagery 14 5.00 Very Low Very Low Very Low
depression 12 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Mechanotransduction 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Injury 116 99.34 Very High Very High Very High
INFLAMMATION 48 85.64 High High
Stress 100 84.72 Quite High
Congenital Anomalies 24 84.44 Quite High
Shock 12 80.52 Quite High
Sprains And Strains 8 76.48 Quite High
Injury 16 67.40 Quite High
Necrosis 6 50.48 Quite High
Cancer 4 50.12 Quite High
Reprotox - General 3 12 35.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-designed and pre-optimized commercially available TaqMan® Gene Expression Assays for MEKK3/Map3k3 (Assay ID: Mm00803725_m1), MKK3/Map2k3 (Assay ID: Mm00435950_m1), MKK6/Map2k6 (Assay ID: Mm00803694_m1), MKK4/Map2k4 (Assay ID: Mm00436508_m1), p38?
Gene_expression (/) of MKK3
1) Confidence 0.65 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Phosphorylated MAP2K3/MAP2K6 was detected in the cytoplasm and the nucleus at all preimplantation stages of mouse development although the nuclear fluorescence was more intense than the cytoplasmic fluorescence.
Gene_expression (detected) of MAP2K3/MAP2K6 in nucleus
2) Confidence 0.65 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Relative abundance of mRNAs encoding Ccm2, Map3k3, Map2k3, Map2k6, Map2k4 and Mapk14 during mouse preimplantation development
Gene_expression (encoding) of Map2k3
3) Confidence 0.65 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Primer pairs were designed and synthesized (Sigma-Aldrich Canada Ltd., Oakville, ON, Canada) for Ccm2, Map3k3, Map2k3, Map2k6, Map2k4, and H2afz based on mouse nucleotide sequences in the Ensembl mouse transcript database.
Gene_expression (synthesized) of Map2k3
4) Confidence 0.65 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Phosphorylated MAP2K3/MAP2K6 (Figure 3 p-MAP2K3/6 1-cell to blastocyst) and phosphorylated MAP2K4 (Figure 3 p-MAP2K4 1-cell to blastocyst) were also detected throughout preimplantation development.
Gene_expression (detected) of MAP2K3/MAP2K6
5) Confidence 0.65 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
To further assess the role of p38 MAPK and JNK1 in VILI, we ventilated mice genetically deficient either in mkk3 (mkk3?
Gene_expression (deficient) of mkk3 associated with lung injury
6) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.77 Pain Relevance 0.04
To further assess the role of p38 MAPK and JNK1 in VILI, we ventilated mice genetically deficient either in mkk3 (mkk3?
Gene_expression (deficient) of mkk3 associated with lung injury
7) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.77 Pain Relevance 0.04
Of particular note is the nearly 40-fold increase over 1-cell levels in Map3k3 expression at the morula stage, and the 12-fold increase over the same period in Map2k3 expression which indicates that MAP3K3 and MAP2K3 may be the primary upstream activators of p38 MAPK during preimplantation development.
Gene_expression (expression) of Map2k3 in morula
8) Confidence 0.58 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Qualitative RT-PCR methods resulted in the detection of mRNA transcripts encoding Ccm2, Map3k3, Map2k3, Map2k6 and Map2k4 producing the expected size amplicons of 371 bp, 374 bp, 387 bp, 395 bp and 363 bp respectively throughout mouse preimplantation development in all 3 experimental replicates (Figure 2A).
Gene_expression (producing) of Map2k3
9) Confidence 0.58 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
In conclusion, we have demonstrated for the first time that transcripts and polypeptides encoding MAP3K3, MAP2K3, MAP2K6, MAP2K4 and CCM2 are expressed and localized throughout mouse preimplantation development.
Gene_expression (expressed) of MAP2K3
10) Confidence 0.58 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
MAP2K3, MAP2K6, and MAP2K4) are present throughout mouse preimplantation development.
Gene_expression (present) of MAP2K3
11) Confidence 0.58 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
Our results indicate that Ccm2 along with upstream p38 MAPK pathway constituents (Map3k3, Map2k3, Map2k6, and Map2k4) are expressed throughout mouse preimplantation development.
Gene_expression (expressed) of Map2k3
12) Confidence 0.58 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
Pre-designed and pre-optimized commercially available TaqMan® Gene Expression Assays for MEKK3/Map3k3 (Assay ID: Mm00803725_m1), MKK3/Map2k3 (Assay ID: Mm00435950_m1), MKK6/Map2k6 (Assay ID: Mm00803694_m1), MKK4/Map2k4 (Assay ID: Mm00436508_m1), p38?
Gene_expression (/) of Map2k3
13) Confidence 0.29 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
CCM2, MAP3K3 and the phosphorylated forms of MAP2K3/MAP2K6 and MAP2K4 were also detected throughout preimplantation development.
Gene_expression (detected) of MAP2K3/MAP2K6
14) Confidence 0.26 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0

General Comments

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