INT202360

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 9.89
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k4) nucleus (Map2k4) kinase activity (Map2k4)
response to stress (Map2k4) cytoplasm (Map2k4)
Anatomy Link Frequency
B cells 4
neuronal 2
retinas 1
nucleus 1
Map2k4 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 190 85.72 High High
Central nervous system 10 72.12 Quite High
anesthesia 10 25.12 Quite Low
ketamine 10 15.84 Low Low
cytokine 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 180 99.28 Very High Very High Very High
Apoptosis 100 99.12 Very High Very High Very High
Stress 238 98.74 Very High Very High Very High
Ganglion Cysts 40 95.64 Very High Very High Very High
Carcinoma 1 91.80 High High
Reperfusion Injury 60 86.48 High High
Cv Unclassified Under Development 180 85.72 High High
Shock 11 82.84 Quite High
Stroke 10 76.96 Quite High
Targeted Disruption 10 59.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other studies have established that JNK/SAPK and MAP2K4 are activated and translocated into the nucleus in response to cellular stress [29,30].
Positive_regulation (activated) of MAP2K4 in nucleus associated with stress
1) Confidence 0.48 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.19 Pain Relevance 0
This is relevant because the accumulation of unfolded proteins in the ER can induce ER stress-mediated apoptosis, and an increase of intracellular Ca2+ can activate SAPK/ERK kinase 1 (SEK1) also called the MAP kinase/extracellular signal-regulated kinase 4 (MEK4)-mediated cell death pathway (Dolmetsch et al 1997).
Positive_regulation (activate) of SEK1 associated with stress, apoptosis and death
2) Confidence 0.16 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 1.48 Pain Relevance 0.18
An increase of intracellular Ca2+ concentration can activate SEK1/MEK4 because SEK1/MEK4 is activated under transiently high concentrations of Ca2+ in B cells (Dolmetsch et al 1997).
Positive_regulation (activate) of MEK4 in B cells
3) Confidence 0.16 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.86 Pain Relevance 0
An increase of intracellular Ca2+ concentration can activate SEK1/MEK4 because SEK1/MEK4 is activated under transiently high concentrations of Ca2+ in B cells (Dolmetsch et al 1997).
Positive_regulation (activate) of SEK1 in B cells
4) Confidence 0.16 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.86 Pain Relevance 0
In addition, our data showed that SEK1/MEK4 was phosphorylated and was related to neuronal cell death in the GCL of ischemic retinas.
Positive_regulation (related) of SEK1 in neuronal associated with death
5) Confidence 0.11 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 1.09 Pain Relevance 0
In addition, our data showed that SEK1/MEK4 was phosphorylated and was related to neuronal cell death in the GCL of ischemic retinas.
Positive_regulation (related) of MEK4 in neuronal associated with death
6) Confidence 0.11 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 1.09 Pain Relevance 0
In ischemic retinas, the numbers of SEK1-, ASK1-, and JNK-positive cells were significantly increased in the GCL compared to those in the control retinas.
Positive_regulation (increased) of SEK1 in retinas
7) Confidence 0.11 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2699777 Disease Relevance 0.69 Pain Relevance 0.11
An increase of intracellular Ca2+ concentration can activate SEK1/MEK4 because SEK1/MEK4 is activated under transiently high concentrations of Ca2+ in B cells (Dolmetsch et al 1997).
Positive_regulation (activated) of SEK1 in B cells
8) Confidence 0.11 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.86 Pain Relevance 0
An increase of intracellular Ca2+ concentration can activate SEK1/MEK4 because SEK1/MEK4 is activated under transiently high concentrations of Ca2+ in B cells (Dolmetsch et al 1997).
Positive_regulation (activated) of MEK4 in B cells
9) Confidence 0.11 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.86 Pain Relevance 0
Both ASK1 and SEK1/MEK4 expression in the GCL was significantly increased only at the initial phase after reperfusion.
Positive_regulation (increased) of SEK1
10) Confidence 0.05 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.97 Pain Relevance 0
Both ASK1 and SEK1/MEK4 expression in the GCL was significantly increased only at the initial phase after reperfusion.
Positive_regulation (increased) of MEK4
11) Confidence 0.05 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.92 Pain Relevance 0

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