INT202361

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 5.53
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mef2c) nucleus (Mef2c) DNA binding (Mef2c)
protein complex (Mef2c) cytoplasm (Mef2c)
Anatomy Link Frequency
ventricle 5
cardiomyocytes 2
TEK 2
heart 2
myocardium 1
Mef2c (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 9 97.36 Very High Very High Very High
cytokine 3 94.56 High High
cINOD 1 92.88 High High
imagery 42 90.32 High High
Central nervous system 12 75.36 Quite High
fibrosis 200 73.32 Quite High
amygdala 2 64.36 Quite High
Hippocampus 6 63.44 Quite High
Pain 8 54.16 Quite High
Action potential 12 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 63 99.98 Very High Very High Very High
Myocardial Infarction 158 98.64 Very High Very High Very High
Congenital Anomalies 42 95.04 Very High Very High Very High
Hypertrophy 181 94.92 High High
Stress 182 93.80 High High
INFLAMMATION 1 92.48 High High
Coronary Heart Disease 260 92.40 High High
Left Ventricular Hypertrophy 200 90.12 High High
Anxiety Disorder 29 79.60 Quite High
Hyperplasia 4 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injections of siGFP (900 µg/Kg) did not affect MEF2C expression levels in the left ventricle in comparison with phosphate buffer saline (Figure 2B).
Gene_expression (expression) of MEF2C in ventricle
1) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
The expression of MEF2C was reduced in cardiomyocytes harvested from the left ventricle 24 hours after the treatment with siMEF2C to similar levels of myocardial extracts (?
Gene_expression (expression) of MEF2C in ventricle
2) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
As shown in Figure 3A, MEF2C protein expression was reduced by approximately 75% in the left ventricle of control mice up to the 4th day after the administration of siMEF2C.
Gene_expression (expression) of MEF2C in ventricle
3) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
Transfection of siMEF2C (300 ng/ml) reduced the MEF2C transcripts in NRVMs by approximately 80% (Figure 1A). siMEF2C had no influence in the amounts of MEF2A, MEF2B or MEF2D transcripts (Figure 1B-D).
Gene_expression (Transfection) of siMEF2C
4) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.25 Pain Relevance 0.03
Finally, forced expressions of either MEF2C or PGC-1?
Gene_expression (expressions) of MEF2C
5) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.41 Pain Relevance 0.03
Moreover, the specificity of MEF2C silencing was substantiated by the lack of effects of siMEF2C on MEF2A, MEF2B or MEF2D, as well as on the unrelated proteins FAK, JNK, SHP2 and GAPDH.
Gene_expression (silencing) of MEF2C
6) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.11 Pain Relevance 0
However, the mechanisms that connect the MEF2C to mTOR/S6K pathway were not explored in the present study.
Gene_expression (connect) of MEF2C
7) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.21 Pain Relevance 0
Moreover, mTOR overactivation has been shown to cause increased mitochondrial biogenesis and accumulation of reactive oxygen species in distinct model systems[36], suggesting that the activation of mTOR pathway might be responsible for the detrimental effects of MEF2C activation and vice-versa to the beneficial effects of MEF2C depletion in the mechanically overloaded hearts.
Gene_expression (depletion) of MEF2C in hearts
8) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.17 Pain Relevance 0
We started off with 450 µg/Kg of siMEF2C based on a previous report[19] and observed an expressive reduction, of about 85%, of myocardial MEF2C protein expression 1 day after bolus injections of 900 µg/Kg of siMEF2C (Figure 2A).
Gene_expression (expression) of MEF2C
9) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
The data gathered in the present study reveal that MEF2C depletion blunted the increases in mtDNA and the ability of the myocardium to sustain the ATP levels when subjected to pressure overload, indicating that MEF2C may play a role in regulating the cardiac mitochondriogenesis and energetic metabolism in response to hypertrophic stimuli.
Gene_expression (depletion) of MEF2C in myocardium
10) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.40 Pain Relevance 0.03
Western blot analysis indicated that MEF2C was reduced in the order of 75%, while no change could be observed in the expression of MEF2A in cells treated with siMEF2C, in comparison with cells treated with siGFP (Figure 1E, F).
Neg (no) Gene_expression (reduced) of MEF2C
11) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.06 Pain Relevance 0
Furthermore, MEF2 factors have been shown to mediate the Ca2+/Calcineurin activation of PGC-1?
Gene_expression (factors) of MEF2
12) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.35 Pain Relevance 0
Accordingly, we have shown here that MEF2C depletion markedly attenuated the rise of PGC-1?
Gene_expression (depletion) of MEF2C
13) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.28 Pain Relevance 0
Overexpression of MEF2A or MEF2C in cultured cardiomyocytes induces sarcomere degeneration and cardiomyocytes elongation, suggesting that activation of these members may compose signaling pathways responsible for pathologic hypertrophy [8].
Gene_expression (Overexpression) of MEF2C in cardiomyocytes associated with hypertrophy
14) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 1.00 Pain Relevance 0.04
Furthermore, the transgenic expression of negative dominants of MEF2 was shown to prevent chamber dilation and mechanical dysfunction, with minor effects on cardiac growth in calcineurin-induced hypertrophy[9].
Gene_expression (expression) of MEF2 associated with targeted disruption and hypertrophy
15) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.78 Pain Relevance 0.04
(iii): MEF2C 1187 antisense: 5?
Gene_expression (antisense) of MEF2C
16) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0.04
As shown in Figure 3A, MEF2C protein expression was reduced by approximately 75% in the left ventricle of control mice up to the 4th day after the administration of siMEF2C.
Gene_expression (expression) of siMEF2C in ventricle
17) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.06 Pain Relevance 0
We found that blood pressure, heart rate, left ventricular structure and function of sham-operated mice were unaffected by siMEF2C, indicating that depletion of MEF2C does not influence basal cardiac function or structure.
Neg (unaffected) Gene_expression (unaffected) of siMEF2C in heart
18) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.36 Pain Relevance 0.03
(ii): MEF2C 1187 sense: 5?
Gene_expression (sense) of MEF2C
19) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0.05
We then set to address the time-course of MEF2C reduction in the left ventricle obtained after systemically delivered siMEF2C.
Gene_expression (reduction) of MEF2C in ventricle
20) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0

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