INT202374

Context Info Confidence 0.37 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.34 Pain Relevance 0.69

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4) cytoplasm (Aqp4)

Anatomy Link Frequency spinal cords 2 astrocytes 2 Aqp4 (Mus musculus)

Pain Link Frequency Relevance Heat Neuropathic pain 8 100.00 Inflammation 3 98.80 Pain 23 78.48 Sciatica 1 46.64 Eae 9 46.52 Spinal cord 15 43.84 allodynia 3 37.28 Acute pain 2 29.80 Sciatic nerve 4 17.92 nociceptor 3 11.68

Disease Link Frequency Relevance Heat Neuropathic Pain 14 100.00 INFLAMMATION 4 98.80 Injury 21 88.56 Syndrome 1 85.44 Pain 26 78.48 Stress 8 67.28 Pressure And Volume Under Development 5 50.64 Nerve Root Compression 1 46.64 Nociception 11 28.84 Targeted Disruption 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

DNA microarray analysis showed significantly increased expression of a number of genes associated with inflammation and astrocytic activation in the spinal cords of rats that developed CNP. mRNA levels of glial fibrilary acidic protein (GFAP) and AQP4 significantly increased in CNP spinal cords of rats.

Negative_regulation (developed) of Transcription (levels) of AQP4 in spinal cords associated with inflammation and neuropathic pain

1) Confidence 0.37 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.27 Pain Relevance 0.69

Interestingly, hyperosmotic treatment of cultured rat astrocytes by mannitol or sorbitol increases the expression of AQP4 and AQP9 mRNAs and proteins, which is suppressed by treatment with the p38 MAPK inhibitor SB203580 [34].

Negative_regulation (suppressed) of Transcription (expression) of AQP4 in astrocytes

2) Confidence 0.25 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0

General Comments

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