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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.34
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
spinal cords 2
astrocytes 2
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 8 100.00 Very High Very High Very High
Inflammation 3 98.80 Very High Very High Very High
Pain 23 78.48 Quite High
Sciatica 1 46.64 Quite Low
Eae 9 46.52 Quite Low
Spinal cord 15 43.84 Quite Low
allodynia 3 37.28 Quite Low
Acute pain 2 29.80 Quite Low
Sciatic nerve 4 17.92 Low Low
nociceptor 3 11.68 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 14 100.00 Very High Very High Very High
INFLAMMATION 4 98.80 Very High Very High Very High
Injury 21 88.56 High High
Syndrome 1 85.44 High High
Pain 26 78.48 Quite High
Stress 8 67.28 Quite High
Pressure And Volume Under Development 5 50.64 Quite High
Nerve Root Compression 1 46.64 Quite Low
Nociception 11 28.84 Quite Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DNA microarray analysis showed significantly increased expression of a number of genes associated with inflammation and astrocytic activation in the spinal cords of rats that developed CNP. mRNA levels of glial fibrilary acidic protein (GFAP) and AQP4 significantly increased in CNP spinal cords of rats.
Negative_regulation (developed) of Transcription (levels) of AQP4 in spinal cords associated with inflammation and neuropathic pain
1) Confidence 0.37 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.27 Pain Relevance 0.69
Interestingly, hyperosmotic treatment of cultured rat astrocytes by mannitol or sorbitol increases the expression of AQP4 and AQP9 mRNAs and proteins, which is suppressed by treatment with the p38 MAPK inhibitor SB203580 [34].
Negative_regulation (suppressed) of Transcription (expression) of AQP4 in astrocytes
2) Confidence 0.25 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0

General Comments

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