INT202378

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.70
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
microglial cells 2
spinal cords 1
choroid plexus 1
brain 1
astrocytes 1
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 8 99.86 Very High Very High Very High
Inflammation 11 98.40 Very High Very High Very High
Central nervous system 48 88.64 High High
Peripheral nervous system 21 81.04 Quite High
Pain 29 77.68 Quite High
Neurotransmitter 10 69.20 Quite High
Sciatica 1 46.64 Quite Low
Eae 9 45.72 Quite Low
Spinal cord 33 43.04 Quite Low
allodynia 3 37.28 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 14 99.86 Very High Very High Very High
INFLAMMATION 12 98.40 Very High Very High Very High
Pressure And Volume Under Development 35 98.00 Very High Very High Very High
Injury 37 87.76 High High
Syndrome 1 84.64 Quite High
Cerebral Edema 16 84.32 Quite High
Pain 32 77.68 Quite High
Autism 16 68.36 Quite High
Stress 30 67.28 Quite High
Targeted Disruption 20 61.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover a recent study demonstrated the expression of AQP4 mRNA and protein within reactive microglial cells in vivo [95].
Transcription (expression) of AQP4 in microglial cells
1) Confidence 0.65 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.11 Pain Relevance 0.26
Tomas-Camardiel and colleagues [95] provided for the first time direct evidence demonstrating the expression of AQP4 mRNA and protein within reactive microglial cells in vivo.
Transcription (expression) of AQP4 in microglial cells
2) Confidence 0.65 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.21 Pain Relevance 0
DNA microarray analysis showed significantly increased expression of a number of genes associated with inflammation and astrocytic activation in the spinal cords of rats that developed CNP. mRNA levels of glial fibrilary acidic protein (GFAP) and AQP4 significantly increased in CNP spinal cords of rats.
Transcription (levels) of AQP4 in spinal cords associated with inflammation and neuropathic pain
3) Confidence 0.59 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.21 Pain Relevance 0.69
More recently, low but significant AQP4 mRNA expression has been associated to the choroid plexus, which is associated to CSF formation [129].
Transcription (expression) of AQP4 in choroid plexus
4) Confidence 0.34 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.10 Pain Relevance 0
Interestingly, hyperosmotic treatment of cultured rat astrocytes by mannitol or sorbitol increases the expression of AQP4 and AQP9 mRNAs and proteins, which is suppressed by treatment with the p38 MAPK inhibitor SB203580 [34].
Transcription (expression) of AQP4 in astrocytes
5) Confidence 0.31 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
AQP4 mRNA was found to be ten times higher in the rat brain compared to the eye, kidney, intestine, or lung [64, 127].
Transcription (found) of AQP4 in brain
6) Confidence 0.25 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0 Pain Relevance 0.06

General Comments

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