INT20238

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Context Info
Confidence 0.61
First Reported 1990
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 11.52
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (APOB) small molecule metabolic process (APOB) endoplasmic reticulum (APOB)
enzyme binding (APOB) lipid metabolic process (APOB) extracellular space (APOB)
Anatomy Link Frequency
coronary artery 2
plasma 1
leukocytes 1
APOB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 56 100.00 Very High Very High Very High
addiction 44 98.98 Very High Very High Very High
Angina 7 94.84 High High
imagery 30 84.36 Quite High
Morphine 36 82.20 Quite High
corticosteroid 13 18.32 Low Low
Onset of action 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Codeine 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 436 100.00 Very High Very High Very High
Cardiovascular Disease 164 100.00 Very High Very High Very High
INFLAMMATION 57 100.00 Very High Very High Very High
Atherosclerosis 75 99.28 Very High Very High Very High
Systemic Sclerosis 107 98.98 Very High Very High Very High
Myocardial Infarction 20 95.88 Very High Very High Very High
Coronary Stenosis 1 95.00 High High
Cv General 3 Under Development 11 94.84 High High
Coronary Artery Disease 34 92.92 High High
Obesity 10 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the existing literature, there is no hard evidence as yet regarding the possible effects of inflammation on apoB levels or the association between apoB and coronary artery disease.
Spec (possible) Regulation (effects) of apoB in coronary artery associated with inflammation and cardiovascular disease
1) Confidence 0.61 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.90 Pain Relevance 0.15
Changes in adiponectin, leptin, and ApoB over time
Regulation (Changes) of ApoB
2) Confidence 0.37 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2935155 Disease Relevance 0.16 Pain Relevance 0
The changes in adiponectin, leptin, and ApoB over time are shown in TableĀ 6.
Regulation (changes) of ApoB
3) Confidence 0.37 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2935155 Disease Relevance 0.16 Pain Relevance 0
When effects of routes of administration were compared with each other (regardless to the duration of addiction), it was found that "Sikh-Sang" presented greater effect on Ch, TG, Lpa, apo B, CRP and fibrinogen (table 2).
Regulation (effect) of apo B associated with addiction
4) Confidence 0.27 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2588593 Disease Relevance 0.38 Pain Relevance 0.43
The results show the deleterious effect of opium on some traditional and new CVD risk factors including HbA1c, HDL-C, Lpa, apo B, factor VII, fibrinogen, apo A and CRP.
Regulation (effect) of apo B associated with cardiovascular disease and disorder of lipid metabolism
5) Confidence 0.27 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2588593 Disease Relevance 1.20 Pain Relevance 0.35
In our study no confounding effect of markers of inflammation (leukocytes, CRP) on apoB levels was established.
Neg (no) Regulation (effect) of apoB in leukocytes associated with inflammation
6) Confidence 0.27 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 1.01 Pain Relevance 0.17
Using stratified and multivariate stepwise regression analysis, it was shown that the apo A1, apoB/apoA1 are more sensitive and specific than the ordinary indices (e.g. total cholesterol, triglycerides, LDL-C and HDL-C) in estimating the degree of coronary artery stenosis and the differentiation of CAD from other diseases.
Regulation (sensitive) of apoB in coronary artery associated with coronary stenosis, coronary artery disease, disease and disorder of lipid metabolism
7) Confidence 0.26 Published 1990 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Abstract Doc Link 2128269 Disease Relevance 1.83 Pain Relevance 0.09
On logistic regression analysis (Tables 5 and 6), the age- and sex-adjusted OR for the presence of CVD was 2.3 (95% confidence interval [CI], 2.0 to 2.7) and 2.0 (95% confidence interval [CI], 1.6 to 2.4) when apoB levels above 1.26 g/L and apoB/apoA-I ratio values above 1.13 were compared with values below these cut-off points, respectively.
Regulation (values) of apoB associated with cardiovascular disease
8) Confidence 0.23 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.59 Pain Relevance 0.03
The effects on plasma cholesterol, TG, HDL, LDL and apolipoproteins A1 (apoA1), B (apoB) and Lp(a) over 4 weeks daily intake of 2-3 times the normal daily intake of SL were examined.
Spec (examined) Regulation (effects) of apoB in plasma associated with disorder of lipid metabolism
9) Confidence 0.20 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2768711 Disease Relevance 0.10 Pain Relevance 0
Furthermore, there were no significant associations between measures of vascular function or atheroma burden and any of: attained LDL-C; change in LDL-C, HDL-C, apoB, apoA-I, or CRP.


Regulation (change) of apoB associated with atherosclerosis and disorder of lipid metabolism
10) Confidence 0.20 Published 2008 Journal Atherosclerosis Section Body Doc Link PMC2292239 Disease Relevance 0.58 Pain Relevance 0.04
The total cholesterol (P < 0.047), the PON1 activity (P < 0.001) and ApoA1 levels (P < 0.001) were significantly lower in MCTD patients than in the controls, while there was no difference in apolipoprotein B concentrations between patients with MCTD and controls (P = 0.693).
Neg (no) Regulation (difference) of apolipoprotein B associated with systemic sclerosis and disorder of lipid metabolism
11) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.98 Pain Relevance 0
The concentrations of TG, TC, LDL-C and apoB-100 along with the ratios of TG/HDL-C, TC/HDL-C, and LDL-C/HDL-C increased successively; however, those of HDL-C and apoA-I decreased progressively with the elevation of the LDL-C/HDL-C ratio.
Regulation (concentrations) of apoB-100 associated with disorder of lipid metabolism
12) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 2.64 Pain Relevance 0

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