INT202384

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Ccm2) cytoplasm (Ccm2)
Anatomy Link Frequency
embryos 1
Ccm2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 48 68.80 Quite High
Reprotox - General 3 6 19.76 Low Low
Increased Venous Pressure Under Development 24 5.00 Very Low Very Low Very Low
Congenital Anomalies 12 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Carcinoma 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of 460 mOsm hyperosmotic treatment on Ccm2 transcripts and CCM2 protein
Regulation (Effect) of CCM2 protein
1) Confidence 0.61 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Though changes were not detected in localization or steady state mRNA transcript levels of CCM2 following hyperosmotic treatment, our results did reveal a significant increase in CCM2 immunofluorescence in blastocysts treated for 15 minutes in 0.2 M sorbitol (460 mOsm), but not 1.4% glycerol (460 mOsm).
Neg (not) Regulation (detected) of CCM2
2) Confidence 0.45 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.06 Pain Relevance 0
While our study has presented a novel discovery in the induction of CCM2 in response to hyperosmotic treatment of preimplantation embryos, much work remains to fully characterize CCM2 activity and regulation during this period of development.


Regulation (regulation) of CCM2 in embryos
3) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
Either of these possibilities would require further study, as very little is currently known about the translational regulation of CCM2 protein, nor is it clear how CCM2-p38 MAPK interactions may be regulated in general.
Regulation (regulation) of CCM2 protein
4) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Effect of 460 mOsm hyperosmotic treatment on Ccm2 transcripts and CCM2 protein
Regulation (Effect) of Ccm2
5) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Despite this outcome, we next investigated whether CCM2 protein levels may be affected.
Spec (may) Regulation (affected) of CCM2 protein
6) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0

General Comments

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