INT202417

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 7.84
Pain Relevance 4.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Gata3) cell morphogenesis (Gata3) DNA binding (Gata3)
signal transduction (Gata3) nucleolus (Gata3) nucleus (Gata3)
Anatomy Link Frequency
T cells 2
joint 1
Th2 T-cell 1
ventral 1
Gata3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 518 100.00 Very High Very High Very High
agonist 81 99.44 Very High Very High Very High
Inflammatory response 59 99.36 Very High Very High Very High
Arthritis 179 99.32 Very High Very High Very High
cytokine 257 99.00 Very High Very High Very High
rheumatoid arthritis 108 89.24 High High
ischemia 51 86.28 High High
b2 receptor 3 84.32 Quite High
antagonist 23 82.44 Quite High
B1 receptor 3 64.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 592 100.00 Very High Very High Very High
Experimental Arthritis 14 99.32 Very High Very High Very High
Obesity 36 98.46 Very High Very High Very High
Arthritis 145 97.60 Very High Very High Very High
Pneumonia 7 96.80 Very High Very High Very High
Apoptosis 82 92.20 High High
Rheumatoid Arthritis 108 89.24 High High
Disease 102 88.48 High High
Asthma 1 88.04 High High
Reperfusion Injury 96 87.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The primer pairs used for locus-ChIP assays of the NeuroD4, Msc, Tcfap2b and Gata3 loci appear in additional file 5.
Gene_expression (assays) of Gata3
1) Confidence 0.61 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0 Pain Relevance 0
However, in one study the TZDs increased IL4 and IL10, and stimulated GATA3 expression (a transcription factor which shifts cells towards Th2 phenotype) [50]; although in other studies PPAR?
Gene_expression (expression) of GATA3
2) Confidence 0.58 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.44 Pain Relevance 0.35
agonists have been shown to inhibit GATA-3 expression and Th2-driven inflammatory responses in murine models [77].
Gene_expression (expression) of GATA-3 associated with inflammatory response and agonist
3) Confidence 0.46 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.75 Pain Relevance 0.30
Although no synthetic inhibitors of GATA-3 currently exist, PPAR-?
Neg (no) Gene_expression (synthetic) of GATA-3
4) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.77 Pain Relevance 0.29
ligands (troglitazone, pioglitazone, and rosiglitazone) increases the expression of the specific Th2 transcription factor, GATA-3.
Gene_expression (expression) of GATA-3
5) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.23 Pain Relevance 0.21
Although no synthetic inhibitors of GATA-3 currently exist, PPAR-?
Gene_expression (exist) of GATA-3
6) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.76 Pain Relevance 0.30
Real-time PCR was performed for GATA-3, T-bet, MCP-1, HO-1, B1R and B2R expression using SYBR Green assay (Applied Biosystem).
Gene_expression (expression) of GATA-3
7) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.06 Pain Relevance 0.15
A further characterization of TS versus ES cells indicated that genes such as Gata3, IRX3, EndoA, Bmp8b, Sin 3b and Gata6 are all more highly expressed in TS cells than in ES cells, indicating that they may play specific roles in TE cell differentiation (Tanaka et al., 2002; Hamatani et al., 2004).
Gene_expression (expressed) of Gata3
8) Confidence 0.38 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0 Pain Relevance 0
It has been suggested that the balance between T-bet and GATA3 expression is crucial for Th1/Th2 T-cell differentiation [62].
Gene_expression (expression) of GATA3 in Th2 T-cell
9) Confidence 0.35 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.26 Pain Relevance 0.14
GATA3 expression polarizes T cells towards a Th2 lineage and represses IFN-?
Gene_expression (expression) of GATA3 in T cells
10) Confidence 0.35 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.14 Pain Relevance 0.15
We found that B1R gene deletion or antagonism resulted in higher expression of the anti-inflammatory GATA-3, IL-4 and IL-10 and lower transcription of the pro-inflammatory T-bet and IL-1?.
Gene_expression (expression) of GATA-3 associated with inflammation
11) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.36 Pain Relevance 0.30
The protection seen under B1R deletion or antagonism was associated with an increased expression of GATA-3, IL-4 and IL-10 and a decreased T-bet and IL-1?
Gene_expression (expression) of GATA-3
12) Confidence 0.30 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2516176 Disease Relevance 0.72 Pain Relevance 0.31
It has been shown that overexpression of the Th2-specific transcription factor, GATA3, in T cells can modulate Th17 cell differentiation and protects against severe joint inflammation and bone erosion in experimental arthritis [88].
Gene_expression (overexpression) of GATA3 in joint associated with inflammation, experimental arthritis and arthritis
13) Confidence 0.29 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.00 Pain Relevance 0.64
Moreover, GATA3 overexpression resulted in reduced gene expression of the Th17-associated transcription factor RORgammat [88].
Gene_expression (overexpression) of GATA3
14) Confidence 0.29 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.01 Pain Relevance 0.63
Notably absent from the list of repressed targets are SSTFs that are known to be expressed specifically in nascent postmitotic ventral interneurons (Evx1, Evx2, En1, Chx10, Sim1, Sox14, Etv1, Etv4, Gata2, Gata3), motor neurons (Isl2, Lhx3, Lhx4, Hlxb9 (Hb9, MNR2)), or the ventral progenitor laminae (Dbx1, Dbx2, Nkx6.2, Nkx6.1, Irx3, Olig1, Olig2, Nkx2.2, Nkx2.9, Pax6, Gli1, Gli2, Gli3).
Gene_expression (expressed) of Gata3 in ventral
15) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
Th1 polarization has been correlated with hyperleptinemia in hemodialysis patients [65] and the protection of ob/ob mice in Th1- as well as in Th2-dependent inflammation is provided by a decreased expression of the key transcription factors for Th1 and Th2 polarization, T-bet and GATA-3 in naive ob/ob T cells.
Gene_expression (expression) of GATA-3 in T cells associated with inflammation and obesity
16) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.34 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox