INT202419

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.47
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Gata3) cell morphogenesis (Gata3) DNA binding (Gata3)
signal transduction (Gata3) nucleolus (Gata3) nucleus (Gata3)
Anatomy Link Frequency
joint 2
Gata3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 178 100.00 Very High Very High Very High
Arthritis 173 99.32 Very High Very High Very High
cytokine 116 99.00 Very High Very High Very High
agonist 35 92.96 High High
Inflammatory response 23 91.00 High High
rheumatoid arthritis 108 89.24 High High
antagonist 21 68.08 Quite High
ischemia 41 59.28 Quite High
fibrosis 3 45.24 Quite Low
Pain 5 30.16 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 198 100.00 Very High Very High Very High
Experimental Arthritis 14 99.32 Very High Very High Very High
Arthritis 139 97.60 Very High Very High Very High
Pneumonia 2 97.24 Very High Very High Very High
Rheumatoid Arthritis 108 89.24 High High
Disease 74 88.92 High High
Reperfusion Injury 96 88.72 High High
Asthma 1 88.48 High High
Multiple Sclerosis 20 82.96 Quite High
Pressure And Volume Under Development 9 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in one study the TZDs increased IL4 and IL10, and stimulated GATA3 expression (a transcription factor which shifts cells towards Th2 phenotype) [50]; although in other studies PPAR?
Positive_regulation (stimulated) of Gene_expression (expression) of GATA3
1) Confidence 0.52 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.44 Pain Relevance 0.36
ligands (troglitazone, pioglitazone, and rosiglitazone) increases the expression of the specific Th2 transcription factor, GATA-3.
Positive_regulation (increases) of Gene_expression (expression) of GATA-3
2) Confidence 0.30 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.23 Pain Relevance 0.21
Real-time PCR was performed for GATA-3, T-bet, MCP-1, HO-1, B1R and B2R expression using SYBR Green assay (Applied Biosystem).
Positive_regulation (performed) of Gene_expression (expression) of GATA-3
3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.06 Pain Relevance 0.15
We found that B1R gene deletion or antagonism resulted in higher expression of the anti-inflammatory GATA-3, IL-4 and IL-10 and lower transcription of the pro-inflammatory T-bet and IL-1?.
Positive_regulation (higher) of Gene_expression (expression) of GATA-3 associated with inflammation
4) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.36 Pain Relevance 0.30
We found that B1R gene deletion or antagonism resulted in higher expression of the anti-inflammatory GATA-3, IL-4 and IL-10 and lower transcription of the pro-inflammatory T-bet and IL-1?.
Positive_regulation (resulted) of Gene_expression (expression) of GATA-3 associated with inflammation
5) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.37 Pain Relevance 0.30
Moreover, GATA3 overexpression resulted in reduced gene expression of the Th17-associated transcription factor RORgammat [88].
Positive_regulation (overexpression) of Gene_expression (overexpression) of GATA3
6) Confidence 0.22 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.01 Pain Relevance 0.63
It has been shown that overexpression of the Th2-specific transcription factor, GATA3, in T cells can modulate Th17 cell differentiation and protects against severe joint inflammation and bone erosion in experimental arthritis [88].
Positive_regulation (overexpression) of Gene_expression (overexpression) of GATA3 in joint associated with inflammation, experimental arthritis and arthritis
7) Confidence 0.22 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.00 Pain Relevance 0.64

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