INT202420

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Anatomy Link Frequency
erythrocyte 1
Jak2 (Rattus norvegicus)
Jak2 - V617F (1)
Pain Link Frequency Relevance Heat
fibrosis 7 35.40 Quite Low
aspirin 43 5.00 Very Low Very Low Very Low
cva 19 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
epidural 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hematological Disease 2 97.16 Very High Very High Very High
Hemorrhagic Thrombocythemia 159 96.34 Very High Very High Very High
Erythremia 2 88.52 High High
Myelodysplastic Syndromes 67 82.12 Quite High
Chromosome Aberrations 4 69.00 Quite High
Fibrosis 13 35.40 Quite Low
Thrombosis 43 5.00 Very Low Very Low Very Low
Hemorrhage 28 5.00 Very Low Very Low Very Low
Myeloproliferative Disorder 26 5.00 Very Low Very Low Very Low
Thrombocytosis 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Absence of the V617F mutation in ET with unquestionable clonal hematopoiesis may however suggest, on the contrary, that other mutation(s) might still explain myeloid expansion in these patients [23-28].

• Prior to the description of the JAK2 V617F mutation, a set of positive markers including 1) "spontaneous" growth of erythrocyte precursors (EEC) in absence of added erythropoietin (EPO) [29]; 2) endogenous megakaryocytic colony formation [30]; 3) decreased expression of c-MPL at platelet or megakaryocyte cell surface; 4) polycythemia rubra vera protein 1 (PRV-1) and 5) nuclear factor erythroid 2 (NF-E2) mRNA over expression in polymorphonuclear cells were initially described in PV patients.

Transcription (description) of JAK2 (V617F) in erythrocyte associated with hemorrhagic thrombocythemia, hematological disease, erythremia and myelodysplastic syndromes
1) Confidence 0.56 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1781427 Disease Relevance 0.91 Pain Relevance 0

General Comments

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