INT202426

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.96
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T-helper cells 1
T cell 1
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 74 100.00 Very High Very High Very High
Potency 2 74.64 Quite High
Inflammation 68 54.40 Quite High
rheumatoid arthritis 1 23.84 Low Low
psoriasis 1 22.08 Low Low
Crohn's disease 4 21.20 Low Low
Multiple sclerosis 1 19.52 Low Low
tolerance 13 19.24 Low Low
headache 11 5.56 Low Low
fibrosis 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphopenia 4 100.00 Very High Very High Very High
Disease 69 99.78 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 220 99.40 Very High Very High Very High
Bronchiectasis 70 98.60 Very High Very High Very High
Immunodeficiency 4 97.84 Very High Very High Very High
Cryptococcus Infection 8 96.44 Very High Very High Very High
Cryptococcal Meningitis 16 92.60 High High
Toxicity 23 86.96 High High
Recurrence 1 83.56 Quite High
Infection 50 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A modelling study from South Africa found a 54% reduction of HIV transmission when therapy is initiated at CD4 <350 cells/?
Transcription (initiated) of CD4 associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.69 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.92 Pain Relevance 0
European and US guidelines recommend ART initiation at a CD4 cell threshold of 350 cells/?
Transcription (threshold) of CD4
2) Confidence 0.69 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.77 Pain Relevance 0.04
CD4/CD8 ratio and cytokine levels of the BAL fluid in patients with bronchiectasis caused by sulfur mustard gas inhalation

Objective

Transcription (levels) of CD4 associated with bronchiectasis and cytokine
3) Confidence 0.40 Published 2007 Journal J Inflamm (Lond) Section Title Doc Link PMC1781448 Disease Relevance 0.47 Pain Relevance 0.17
RORgammat induces transcription of the genes encoding IL-17 and the related cytokine IL-17F in naive CD4+ T-helper cells and is required for their expression in response to IL-6 and TGF-beta, the cytokines known to induce IL-17.
Transcription (transcription) of CD4 in T-helper cells associated with cytokine
4) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.11 Pain Relevance 0.20
CD4 T cell responses to Env, Gag and Nef were detected after DNA prime and after Ad5 boost, but no Pol specific responses were seen.
Transcription (detected) of CD4 in T cell
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943475 Disease Relevance 0.07 Pain Relevance 0.08
Most patients (81%) have no concomitant immunosuppressive disease, although CD4 lymphopenia was detected in 9 patients, 3 of whom had no other underlying conditions.
Transcription (detected) of CD4 associated with lymphopenia and disease
6) Confidence 0.15 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2910700 Disease Relevance 1.62 Pain Relevance 0

General Comments

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