INT202428

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.11
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
CD86 2
macrophage 2
regulatory T cells 2
lung 2
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 49 99.78 Very High Very High Very High
cytokine 53 96.60 Very High Very High Very High
Inflammation 48 91.96 High High
antagonist 6 77.32 Quite High
Central nervous system 7 67.64 Quite High
chemokine 11 59.08 Quite High
agonist 12 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dementia 6 98.80 Very High Very High Very High
Bronchiectasis 70 98.64 Very High Very High Very High
Injury 3 98.12 Very High Very High Very High
Malignant Neoplastic Disease 13 92.72 High High
Apoptosis 63 92.20 High High
INFLAMMATION 59 91.96 High High
Autoimmune Disease 1 91.20 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 45 89.52 High High
Viral Meningitis 7 89.04 High High
Adhesions 6 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the stimuli and the mechanisms that mediate CD4 T-cell recruitment to the lung of our patients with bronchiectasis are not understood.
Positive_regulation (mediate) of CD4 Binding (recruitment) of in lung associated with bronchiectasis
1) Confidence 0.37 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1781448 Disease Relevance 1.00 Pain Relevance 0.35
In addition, Dunfee et al. found that asparagine in position 283 (N283) in gp120's C2 region seems to be more common in Env from brain than from lymphoid tissues, associates with the presence of dementia and could contribute to the lower CD4 dependence, slightly increased affinity for CD4 and enhanced macrophage tropism [53].
Positive_regulation (increased) of CD4 Binding (affinity) of in macrophage associated with addiction and dementia
2) Confidence 0.33 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.51 Pain Relevance 0.27
activation enhanced the generation of CD4+ CD25+ regulatory T cells (Tregs).
Positive_regulation (enhanced) of CD4 Binding (generation) of in regulatory T cells
3) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.38 Pain Relevance 0.06
0.0001), accessory molecules (CD4, CD80, CD86, CD28 and CD152; P?
Positive_regulation (molecules) of CD4 Binding (0.0001) of in CD86
4) Confidence 0.13 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.21 Pain Relevance 0

General Comments

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