INT202435

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.44
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGF2) extracellular region (IGF2) carbohydrate metabolic process (IGF2)
IGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 97.60 Very High Very High Very High
Dopamine 83 91.04 High High
midbrain 20 80.56 Quite High
chemokine 2 74.68 Quite High
Action potential 4 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 84 99.46 Very High Very High Very High
Medulloblastoma 2 94.36 High High
Gastrointestinal Stromal Tumor 27 92.72 High High
Malignant Neoplastic Disease 4 91.84 High High
Adenocarcinoma 50 87.60 High High
Death 2 87.00 High High
Colon Cancer 2 83.56 Quite High
Cervical Cancer 6 79.64 Quite High
Apoptosis 2 78.08 Quite High
Adhesions 2 74.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization of the tumor samples demonstrated high expression of IGF II mRNA and elevated pro-IGF II (figure 3).
Transcription (expression) of IGF II associated with cancer
1) Confidence 0.58 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.55 Pain Relevance 0
Since the most studied IGF2BP3-regulated mRNA transcript is IGF-2, we examined the protein expression of IGF-2 in relation to that of IGF2BP3.
Transcription (transcript) of IGF-2
2) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.46 Pain Relevance 0
Decreases in IGF-2 mRNA levels and IGF-2 secretion using growth hormone-releasing hormone antagonists were associated with decreased cancer cell proliferation in vitro [32] and tumor growth in vivo [33,34].
Transcription (levels) of IGF-2 associated with cancer and antagonist
3) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 1.43 Pain Relevance 0.05
The IGF2 and H19 transcripts were most abundant of the 11,912 distinct sequences detected.
Transcription (transcripts) of IGF2
4) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.24

General Comments

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