INT202476

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.65
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rela) nucleus (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Rela (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 78 99.98 Very High Very High Very High
cytokine 108 97.44 Very High Very High Very High
Inflammation 70 90.96 High High
Inflammatory response 16 88.64 High High
opiate 18 79.64 Quite High
metalloproteinase 5 72.56 Quite High
Inflammatory mediators 7 62.96 Quite High
Substantia nigra 74 56.32 Quite High
dopaminergic neurodegeneration 10 50.00 Quite Low
agonist 2 42.16 Quite Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 27 100.00 Very High Very High Very High
Cancer 14 97.76 Very High Very High Very High
Targeted Disruption 31 97.64 Very High Very High Very High
Sarcoma 7 97.20 Very High Very High Very High
Stress 35 95.56 Very High Very High Very High
Sprains And Strains 19 93.96 High High
Hypertrophy 12 91.16 High High
INFLAMMATION 97 90.96 High High
Necrosis 15 90.04 High High
Apoptosis 23 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chelating [Ca2+]i prevented Tat±morphine-induced p65/NF-?
Positive_regulation (induced) of Gene_expression (/) of p65 associated with morphine
1) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.20 Pain Relevance 0.94
HV68 in cell culture is blocked by overexpression of p65, and it has been proposed that NF-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of p65
2) Confidence 0.34 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.41 Pain Relevance 0
The transcriptional activation of p65 and p50, the accumulation of p65 protein, and the induction of ICAM-1 were all attenuated in the Fc?
Positive_regulation (accumulation) of Gene_expression (protein) of p65
3) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0.03
Interestingly, they do not appear to have an increase in cytoplasmic p65 at baseline, as evidenced by the low level of p65 staining observed using immunohistochemistry (Figure 2C).
Positive_regulation (level) of Gene_expression (staining) of p65
4) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0
Immunohistochemical staining was performed with an antibody against the activated p65 subunit of NF-?
Positive_regulation (activated) of Gene_expression (subunit) of p65
5) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2697669 Disease Relevance 0.56 Pain Relevance 0.05
B-p65 and -p50 expression after exposure in Ppar?
Positive_regulation (-) of Gene_expression (expression) of p65
6) Confidence 0.18 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.43 Pain Relevance 0.08
B subunit (but with normal p65 expression) subjected to myocardial infarction had an increased remodelling in the form of larger end-diastolic volume and reduced ejection fraction compared to wild type [50].
Positive_regulation (increased) of Gene_expression (expression) of p65 associated with myocardial infarction
7) Confidence 0.18 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.63 Pain Relevance 0.12
The co-transfection of RNAi against Keap1 and p65 reversed the phenotypic effect seen with individual Keap1 knock down (Fig. 5D).
Positive_regulation (transfection) of Gene_expression (transfection) of p65 associated with targeted disruption
8) Confidence 0.11 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.51 Pain Relevance 0
B subunit RelA, thereby reducing its
Positive_regulation (subunit) of Gene_expression (subunit) of RelA
9) Confidence 0.10 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 0.77 Pain Relevance 0
PA increased the protein expression of subunit p65 of NF-?
Positive_regulation (increased) of Gene_expression (expression) of p65
10) Confidence 0.03 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.13 Pain Relevance 0

General Comments

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