INT202485

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.28
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd22) plasma membrane (Cd22)
Anatomy Link Frequency
B cells 2
marginal zone 1
platelets 1
Cd22 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 8 94.44 High High
rheumatoid arthritis 48 94.32 High High
Inflammation 15 70.32 Quite High
spastic colon 1 63.44 Quite High
Adalimumab 8 62.00 Quite High
cytokine 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 58 99.98 Very High Very High Very High
B-cell Chronic Lymphocytic Leukemia 12 98.92 Very High Very High Very High
Arthritis 8 94.44 High High
Rheumatoid Arthritis 48 94.32 High High
Disease Progression 1 88.88 High High
B-cell Lymphoma 2 86.88 High High
Targeted Disruption 17 85.00 Quite High
Infection 77 82.08 Quite High
Apoptosis 7 81.44 Quite High
Follicular Lymphoma 25 81.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunophenotype of marginal lymphomas is distinct from other small lymphocytic lymphomas: the antigen profile for the marginal zone lymphomas include CD19, CD20, CD22 positive and CD5, CD10, CD23, and CD11C negative.
Positive_regulation (include) of CD22 in marginal zone associated with b-cell chronic lymphocytic leukemia and lymphatic system cancer
1) Confidence 0.19 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.14 Pain Relevance 0
B cells fail to enter S phase upon B-cell receptor activation, a block in cell cycle progression that is attributed to the failure to induce the transcription of G1 cyclins D3 and E, which in turn leads to a loss of cdk activity and delayed pRB phosphorylation [66].
Positive_regulation (activation) of B-cell receptor in B-cell
2) Confidence 0.08 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.22 Pain Relevance 0
HS1 is tyrosine phosphorylated downstream of T- and B-cell receptor activation [13] and following thrombin-stimulation of platelets [14].
Positive_regulation (activation) of B-cell receptor in platelets
3) Confidence 0.08 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.08 Pain Relevance 0
CD86 is upregulated on activated B cells upon B-cell receptor (BCR) and CD19/CD21 complex engagement [24,25].
Positive_regulation (upregulated) of B-cell receptor in B cells
4) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.84 Pain Relevance 0.30

General Comments

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