INT202494

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.17
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Chuk) nucleus (Chuk) kinase activity (Chuk)
cytoplasm (Chuk)
Chuk (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 65 82.24 Quite High
Inflammation 111 81.60 Quite High
cytokine 130 72.96 Quite High
metalloproteinase 8 72.92 Quite High
Arthritis 15 72.16 Quite High
Bioavailability 6 41.44 Quite Low
Inflammatory mediators 19 26.96 Quite Low
chemokine 9 16.72 Low Low
COX2 2 9.12 Low Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 81 98.04 Very High Very High Very High
Hypertrophy 10 95.92 Very High Very High Very High
Natriuresis 1 91.20 High High
Targeted Disruption 28 82.96 Quite High
Rheumatoid Arthritis 65 82.24 Quite High
INFLAMMATION 148 81.60 Quite High
Arthritis 18 76.20 Quite High
Disease Progression 2 74.40 Quite High
Obesity 244 68.04 Quite High
Myocardial Infarction 27 65.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-10 has been reported to reduce the activity of the IKK signalosome and induce the translocation of NF-?
Regulation (activity) of IKK
1) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.58 Pain Relevance 0.28
M might reflect (i) the utilization of alternative NIK/IKK1-mediated NF-?
Regulation (alternative) of IKK1
2) Confidence 0.14 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.33 Pain Relevance 0
Inhibitors targeting IKK have so far proven to be the most effective compounds for preventing the activation of NF-?
Regulation (targeting) of IKK
3) Confidence 0.13 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 0.32 Pain Relevance 0.07
B activation by cardiospecific deletion of NEMO, a regulatory subunit of the IKK?
Regulation (regulatory) of IKK
4) Confidence 0.06 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.61 Pain Relevance 0.04
B activation [29] and has recently been shown to specifically target IKK [24].
Regulation (target) of IKK
5) Confidence 0.06 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 0.33 Pain Relevance 0.07

General Comments

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