INT202518

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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mrpl14) structural constituent of ribosome (Mrpl14) ribosome (Mrpl14)
translation (Mrpl14)
Anatomy Link Frequency
macrophages 1
neutrophils 1
Mrpl14 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 4 98.84 Very High Very High Very High
Inflammation 4 97.36 Very High Very High Very High
Endogenous opioid 2 95.84 Very High Very High Very High
antinociception 8 90.80 High High
IPN 4 81.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 97.36 Very High Very High Very High
Inflammatory Pain 4 81.92 Quite High
Peritonitis 2 69.96 Quite High
Nociception 2 58.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: We have previously shown that the calcium-binding protein MRP-14 secreted by neutrophils mediates the antinociceptive response in an acute inflammatory model induced by the intraperitoneal injection of glycogen in mice.
Localization (secreted) of MRP-14 in neutrophils associated with inflammation and antinociceptive
1) Confidence 0.77 Published 2002 Journal Mediators Inflamm Section Abstract Doc Link PMC1781669 Disease Relevance 0.18 Pain Relevance 0.26
This suggests that the enhancement of the effect observed after treatment with the anti-neutrophil antibody may be due to secretion of MRP-14 by macrophages.
Localization (secretion) of MRP-14 in macrophages
2) Confidence 0.77 Published 2002 Journal Mediators Inflamm Section Abstract Doc Link PMC1781669 Disease Relevance 0.13 Pain Relevance 0.45

General Comments

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