INT202519

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.88
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mrpl14) structural constituent of ribosome (Mrpl14) ribosome (Mrpl14)
translation (Mrpl14)
Anatomy Link Frequency
neutrophils 3
peritoneal macrophages 1
Mrpl14 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 16 98.84 Very High Very High Very High
Antinociceptive 8 98.48 Very High Very High Very High
IPN 8 98.12 Very High Very High Very High
Inflammation 8 97.00 Very High Very High Very High
Endogenous opioid 4 92.60 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 8 98.12 Very High Very High Very High
INFLAMMATION 8 97.00 Very High Very High Very High
Peritonitis 4 78.04 Quite High
Nociception 4 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: We have previously shown that the calcium-binding protein MRP-14 secreted by neutrophils mediates the antinociceptive response in an acute inflammatory model induced by the intraperitoneal injection of glycogen in mice.
MRP-14 Binding (binding) of in neutrophils associated with inflammation and antinociceptive
1) Confidence 0.46 Published 2002 Journal Mediators Inflamm Section Abstract Doc Link PMC1781669 Disease Relevance 0.18 Pain Relevance 0.25
After 4 h of Cg injection in neutrophil-depleted mice a significant expression of the calcium-binding protein MRP-14 was detected in the cytoplasm of peritoneal macrophages.
MRP-14 Binding (binding) of in peritoneal macrophages
2) Confidence 0.34 Published 2002 Journal Mediators Inflamm Section Abstract Doc Link PMC1781669 Disease Relevance 0.14 Pain Relevance 0.44
CONCLUSION: These data support the hypothesis that neutrophils and the calcium-binding protein MRP-14 are participants of the endogenous control of inflammatory pain in mice despite the model of acute inflammation used.



MRP-14 Binding (binding) of in neutrophils associated with inflammation and ipn
3) Confidence 0.34 Published 2002 Journal Mediators Inflamm Section Abstract Doc Link PMC1781669 Disease Relevance 0.25 Pain Relevance 0.57
Neutrophils and the calcium-binding protein MRP-14 mediate carrageenan-induced antinociception in mice.


MRP-14 Binding (binding) of in Neutrophils associated with antinociception
4) Confidence 0.34 Published 2002 Journal Mediators Inflamm Section Title Doc Link PMC1781669 Disease Relevance 0.30 Pain Relevance 0.36

General Comments

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