INT202522

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 5.90
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cftr) transport (Cftr) ATPase activity (Cftr)
enzyme binding (Cftr) protein complex (Cftr) transmembrane transport (Cftr)
Anatomy Link Frequency
Caco-2 6
Cftr (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 399 100.00 Very High Very High Very High
cINOD 6 99.98 Very High Very High Very High
aspirin 32 98.94 Very High Very High Very High
Inflammation 86 90.04 High High
abdominal pain 9 55.12 Quite High
cytokine 9 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 399 100.00 Very High Very High Very High
INFLAMMATION 67 99.86 Very High Very High Very High
Infection 57 98.68 Very High Very High Very High
Disorder Of Lipid Metabolism 108 97.80 Very High Very High Very High
Disease 34 91.16 High High
Diabetes Mellitus 9 91.00 High High
Hypersensitivity 6 90.36 High High
Dyslipidemia /

Combined Dyslipidemia

9 89.12 High High
Steatorrhea 18 89.04 High High
Stress 9 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To elucidate the mechanisms underlying the significant raise of FA upon reduction in CFTR expression, we assessed the expression of two proteins involved in FA intestinal uptake and transport.
Negative_regulation (reduction) of Gene_expression (expression) of CFTR
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.17 Pain Relevance 0
Finally, specific transcription factors involved in the regulation of lipid metabolism are strongly suppressed in the presence of reduced CFTR expression.
Negative_regulation (reduced) of Gene_expression (expression) of CFTR
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.27 Pain Relevance 0.11
Finally, specific transcription factors involved in the regulation of lipid metabolism are strongly suppressed in the presence of reduced CFTR expression.
Negative_regulation (suppressed) of Gene_expression (expression) of CFTR
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.32 Pain Relevance 0.13
Using the intestinal Caco-2/15 cell model, we could show that, reduced CFTR expression distinctively affects the different classes of FA.
Negative_regulation (reduced) of Gene_expression (expression) of CFTR in Caco-2
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.44 Pain Relevance 0.14
Aspirin and some other nonsteroidal anti-inflammatory drugs inhibit cystic fibrosis transmembrane conductance regulator protein gene expression in T-84 cells.


Negative_regulation (inhibit) of Gene_expression (expression) of cystic fibrosis transmembrane conductance regulator protein gene associated with fibrosis, aspirin, inflammation, cystic fibrosis and cinod
5) Confidence 0.56 Published 1999 Journal Mediators Inflamm Section Title Doc Link PMC1781806 Disease Relevance 1.03 Pain Relevance 0.80
Infection of Caco-2/15 cells with lentivirus carrying CFTR-shRNAi caused a reduction in CFTR gene (61%) and protein (57%) expression when compared to non-infected cells (Figure 1).
Negative_regulation (reduction) of Gene_expression (expression) of CFTR gene in Caco-2 associated with infection
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.10 Pain Relevance 0
Reduction in CFTR expression appears to cause a shift in the balance between energy-yielding and energy-consuming reactions in favor of the latter.
Negative_regulation (Reduction) of Gene_expression (expression) of CFTR
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0 Pain Relevance 0
The absence of CFTR or its F508del mutation (known to promote CFTR degradation) may increase cPLA2?
Negative_regulation (absence) of Gene_expression (mutation) of CFTR
8) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.47 Pain Relevance 0.15
Thus, in addition to changes in AA levels and cPLAa activity, an increased PGES activity could be a possible interpretation of PGE2 elevation in CFTR -/- mice.
Spec (possible) Negative_regulation (interpretation) of Gene_expression (elevation) of CFTR
9) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.49 Pain Relevance 0.21
The absence of CFTR or its F508del mutation (known to promote CFTR degradation) may increase cPLA2?
Negative_regulation (its) of Gene_expression (mutation) of CFTR
10) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.47 Pain Relevance 0.12
Recent work in our lab has addressed the consequences of reduced CFTR expression on the handling, transport and secretion of lipids by the intestinal Caco-2/15 cell line and has shown that CFTR disruption exerted a stimulated action on intestinal lipid synthesis and transport [23].
Negative_regulation (reduced) of Gene_expression (expression) of CFTR in Caco-2
11) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.81 Pain Relevance 0.24
In particular, we could document that disruption of CFTR expression led to a higher cellular FA content characterized by an elevated proportion of saturated and n-7 FA.
Negative_regulation (disruption) of Gene_expression (expression) of CFTR
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.15 Pain Relevance 0.08
Furthermore, the present findings have revealed that CFTR reduced expression is associated with increased de novo lipogenesis.
Negative_regulation (reduced) of Gene_expression (expression) of CFTR
13) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 1.09 Pain Relevance 0.25

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