INT202548

Context Info Confidence 0.20 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.27 Pain Relevance 1.20

growth (Re)

Anatomy Link Frequency liver 1 nerve 1 Re (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 48 99.68 isoflurane 36 97.92 lidocaine 102 94.56 Inflammation 140 93.68 intrathecal 12 85.40 cytokine 70 70.24 chemokine 21 69.92 Neuropathic pain 27 50.00 Inflammatory response 15 28.96 Lasting pain 4 23.76

Disease Link Frequency Relevance Heat Liver Cancer 3 100.00 Nervous System Injury 55 98.08 INFLAMMATION 159 93.68 Cancer 40 92.56 Hepatocellular Cancer 47 91.60 Hepatitis C Virus Infection 8 89.68 Hepatitis B Virus Infection 8 89.36 Parasitic Infection 1 76.40 Helminth Infection 1 74.00 Hypersensitivity 16 66.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

22 h, thus shortening Ri by >50% from ?

Positive_regulation (shortening) of Ri

1) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.23 Pain Relevance 0.87

-deficient mice, DEN-induced liver cancer increased and JNK activation was elevated simultaneously [29].

Positive_regulation (increased) of DEN-induced in liver associated with liver cancer

2) Confidence 0.16 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.05 Pain Relevance 0.07

RI mRNA was up-regulated in the spinal cord and DRG, ipsilateral to the nerve injury (Fig. 8C).

Positive_regulation (up-regulated) of RI in nerve associated with nervous system injury and spinal cord

3) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2669449 Disease Relevance 0.50 Pain Relevance 0.26

It is also acceptable that total IgE levels were not directly correlated to FcåRI upregulation levels [40,42].

Positive_regulation (upregulation) of RI

4) Confidence 0.01 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.49 Pain Relevance 0

General Comments

This test has worked.