INT202577

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 1.30
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DIO2) plasma membrane (DIO2) cellular nitrogen compound metabolic process (DIO2)
Anatomy Link Frequency
joint 1
muscle 1
dorsal horn 1
DIO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 76 99.98 Very High Very High Very High
Spinal cord 44 99.52 Very High Very High Very High
Dorsal horn 5 99.28 Very High Very High Very High
antagonist 98 99.08 Very High Very High Very High
Serotonin 108 99.06 Very High Very High Very High
Dopamine 296 98.48 Very High Very High Very High
agonist 78 97.24 Very High Very High Very High
Bioavailability 10 90.16 High High
Duloxetine 99 81.64 Quite High
cva 11 79.60 Quite High
Disease Link Frequency Relevance Heat
Stress 46 97.48 Very High Very High Very High
Dizziness 6 79.84 Quite High
Cv General 3 Under Development 9 79.60 Quite High
Vomiting 30 79.28 Quite High
Constipation 15 70.56 Quite High
Sleep Disorders 15 69.88 Quite High
Attention Deficit Hyperactivity Disorder 82 67.96 Quite High
Reprotox - General 2 18 57.68 Quite High
Tics 12 51.28 Quite High
Onchocerciasis 16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In each model the predictors were d2 at a single locus and a measure of d2 calculated across all remaining loci, omitting the locus under consideration.
Localization (measure) of d2
1) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0.10 Pain Relevance 0
In each model the predictors were d2 at a single locus and a measure of d2 calculated across all remaining loci, omitting the locus under consideration.
Localization (measure) of d2
2) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0.10 Pain Relevance 0
The innervation of both D1 and D2 receptor by the singular nigrostriatal axon within the nigrostriatal locus responsible for movement control in both agonist and antagonist muscle around the given joint makes our hypothesis both plausible and testable and provides a theoretical framework for experimental studies both in a laboratory and clinical arena.
Localization (receptor) of D2 in joint associated with antagonist and agonist
3) Confidence 0.39 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0 Pain Relevance 0.46
The same nigrostriatal axons simultaneously innervate the agonist/antagonist muscle pairs so that the consecutive stimulation of D1 and D2 receptors enables the synchronized D1-mediated tone inhibition and D2-promoted acceleration of contraction in the antagonist muscle pair.
Localization (acceleration) of D2-promoted in muscle associated with antagonist and agonist
4) Confidence 0.34 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.05 Pain Relevance 0.57
Milnacipran inhibits noradrenaline and serotonin uptake at presynaptic sites.169 Despite the high affinity for both serotonin and noradrenaline transporters, noradrenaline reuptake is preferentially blocked.170 Postsynaptic cholinergic, adrenergic, H1, D2, and serotonergic receptors are not affected.171,172
Localization (reuptake) of D2 associated with noradrenaline and serotonin
5) Confidence 0.20 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.36 Pain Relevance 0.51
Milnacipran inhibits noradrenaline and serotonin uptake at presynaptic sites.169 Despite the high affinity for both serotonin and noradrenaline transporters, noradrenaline reuptake is preferentially blocked.170 Postsynaptic cholinergic, adrenergic, H1, D2, and serotonergic receptors are not affected.171,172
Localization (blocked.170) of D2 associated with noradrenaline and serotonin
6) Confidence 0.20 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.35 Pain Relevance 0.50
1, and D2 receptors.180
Localization (receptors.180) of D2
7) Confidence 0.17 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0 Pain Relevance 0.40
In the same way, at the spinal cord level, the predominant localization of D2 receptors in the dorsal horn confirms earlier investigations in the rat [67] and perfectly matches the high dopaminergic fiber density in the dorsal horn of both rodents and NHP spinal cord [39].


Localization (localization) of D2 in dorsal horn associated with dorsal horn and spinal cord
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.31
Acknowledging this ambiguity, the observed associations may be understood in the context of the relative neuroanatomical localization of the D2 and D4 receptors.
Localization (localization) of D2
9) Confidence 0.13 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.07 Pain Relevance 0.09
However, due to their early appearance (D2), these lesions can be considered as a warning signal indicating patients who might be about to develop neurological reactions.
Localization (appearance) of D2
10) Confidence 0.01 Published 2003 Journal Filaria J Section Body Doc Link PMC2147657 Disease Relevance 0.28 Pain Relevance 0.14

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