INT202579

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.11
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (DRD2) plasma membrane (DRD2) signal transducer activity (DRD2)
Anatomy Link Frequency
striatum 4
putamen 2
brain 2
DRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 283 98.16 Very High Very High Very High
drug abuse 16 97.44 Very High Very High Very High
imagery 36 87.48 High High
cocaine 20 87.48 High High
Glutamate 3 87.20 High High
positron emission tomography 56 87.16 High High
Neurotransmitter 64 71.44 Quite High
monoamine 8 65.28 Quite High
antagonist 8 64.32 Quite High
Cannabinoid receptor 1 50.80 Quite High
Disease Link Frequency Relevance Heat
Body Weight 4 100.00 Very High Very High Very High
Substance Abuse 36 97.44 Very High Very High Very High
Impulse Control Disorders 5 86.04 High High
Alcohol Addiction 21 82.04 Quite High
Drug Dependence 3 81.04 Quite High
Attention Deficit Hyperactivity Disorder 688 65.84 Quite High
Disease 71 50.00 Quite Low
Hypersensitivity 2 8.92 Low Low
Syndrome 59 5.00 Very Low Very Low Very Low
Conduct Disorder 46 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a preliminary report in which four Mn-exposed animal were used, they found no significant effect of Mn exposure (mean cumulative Mn dose, 165.5 mg Mn/kg body weight; range, 152–174 mg Mn/kg body weight) on DAT or D2R receptor levels using autoradiography or tyrosine hydroxylase immunohistochemistry, or on the concentration of dopamine and its metabolite homovanillic acid (HVA) measured by HPLC with electrochemical detection in the caudate or putamen, relative to naive controls (Guilarte et al. 2006a).
Neg (no) Regulation (effect) of Gene_expression (levels) of D2R receptor in putamen associated with dopamine and body weight
1) Confidence 0.41 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.20 Pain Relevance 0.32
It is not in any known regulatory region, and although the A1 allele is associated with a decrease in dopamine D2 binding and glucose metabolic rates in many brain regions [83,89,90], its mechanism for influencing DRD2 expression is unknown.
Regulation (influencing) of Gene_expression (expression) of DRD2 in brain associated with dopamine
2) Confidence 0.26 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.43 Pain Relevance 0.34
These findings indicate that methylphenidate effects on D2R expression in the striatum are sensitive not only to length of treatment but also to the developmental stage at which treatment is given.
Regulation (effects) of Gene_expression (expression) of D2R in striatum
3) Confidence 0.15 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.21 Pain Relevance 0.17
These findings indicate that methylphenidate effects on D2R expression in the striatum are sensitive not only to length of treatment but also to the developmental stage at which treatment is given.
Regulation (sensitive) of Gene_expression (expression) of D2R in striatum
4) Confidence 0.06 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.27 Pain Relevance 0.17

General Comments

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