INT202581

Context Info Confidence 0.49 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.81 Pain Relevance 0.47

pigmentation (DRD2) plasma membrane (DRD2) signal transducer activity (DRD2)

Anatomy Link Frequency striatum 2 DRD2 (Homo sapiens)

Pain Link Frequency Relevance Heat positron emission tomography 46 97.92 Dopamine 89 88.72 imagery 24 80.36 Substantia nigra 6 51.68 monoamine 6 5.00 midbrain 5 5.00 Neurotransmitter 4 5.00 addiction 4 5.00 alcohol 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Disease 67 99.50 Parkinsonian Disorders 39 91.36 Liver Disease 12 78.92 Attention Deficit Hyperactivity Disorder 80 68.52 Congenital Anomalies 15 67.20 Neurodegenerative Disease 2 28.32 Tremor 12 5.00 Nerve Degeneration 7 5.00 Hypokinesia 5 5.00 Drug Induced Neurotoxicity 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Repeating the principal analyses in the largest single racial group, those with European ancestry, the main effect of DRD2 on DDT k values was marginally significant (F (1,74) = 3.487, p = .066, ?

Positive_regulation (on) of Gene_expression (effect) of DRD2

1) Confidence 0.49 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.07 Pain Relevance 0

Importantly, PD patients have normal or increased levels of D2R in the striatum (Table 2).

Positive_regulation (increased) of Gene_expression (levels) of D2R in striatum associated with disease

2) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.74 Pain Relevance 0.47

General Comments

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