INT20260

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Context Info
Confidence 0.64
First Reported 1988
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 41
Total Number 42
Disease Relevance 21.48
Pain Relevance 18.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Chkb)
Anatomy Link Frequency
PVN 3
plasma 2
upper 2
macrophage 1
muscle 1
Chkb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 44 100.00 Very High Very High Very High
ischemia 67 99.98 Very High Very High Very High
Pain 171 99.74 Very High Very High Very High
Pain threshold 15 99.62 Very High Very High Very High
Glutamate 17 99.54 Very High Very High Very High
Acupuncture 11 99.26 Very High Very High Very High
narcan 8 99.22 Very High Very High Very High
antagonist 34 98.96 Very High Very High Very High
substance P 7 98.88 Very High Very High Very High
Spinal cord 22 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 3 100.00 Very High Very High Very High
Coronary Artery Disease 16 99.98 Very High Very High Very High
Injury 81 99.76 Very High Very High Very High
Pain 228 99.74 Very High Very High Very High
Death 14 99.72 Very High Very High Very High
Fatigue 6 99.52 Very High Very High Very High
Diabetes Mellitus 245 99.46 Very High Very High Very High
Myalgia 17 99.42 Very High Very High Very High
Asthenia 8 99.36 Very High Very High Very High
Infarction 6 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that noxious heat stimulation mainly leads to increase in Met-EK, and that this peptide originates mainly, from peripheral cells containing opioid peptides such as immune cells and/or Merkel cells, not from primary afferent fibers.
Positive_regulation (increase) of Met-EK in Merkel cells associated with primary afferent fibers and opioid
1) Confidence 0.64 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8278628 Disease Relevance 0.12 Pain Relevance 0.75
Myocardial ischemia enhanced the serum LDH, CK and CK-MB activities and caused premature beats.
Positive_regulation (enhanced) of CK-MB associated with heart rate under development, coronary artery disease and ischemia
2) Confidence 0.56 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 1.05 Pain Relevance 0.17
Myocardial ischemia enhanced the serum LDH, CK and CK-MB activities and caused premature beats.
Positive_regulation (enhanced) of CK associated with heart rate under development, coronary artery disease and ischemia
3) Confidence 0.56 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 0.99 Pain Relevance 0.17
In vivo pre-treatment with the opioid receptor antagonist D,L-naloxone completely eliminated the reperfusion-induced creatine kinase (CK) leakage from the rat isolated perfused haert.
Positive_regulation (induced) of CK associated with antagonist, narcan and opioid receptor
4) Confidence 0.52 Published 2000 Journal Ross Fiziol Zh Im I M Sechenova Section Abstract Doc Link 10808507 Disease Relevance 0.07 Pain Relevance 0.55
Although the incidence of myalgia was low in both groups, the CK levels significantly increased in both groups when checked 24s hour after anesthetic induction time.
Positive_regulation (increased) of CK associated with myalgia
5) Confidence 0.48 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2880274 Disease Relevance 1.01 Pain Relevance 0.53
High-pressure liquid chromatography of the perfusate revealed that noxious heat stimulation induced increase in release of Leu-enkephalin (Leu-EK) as well as Met-EK, although the maximal concentration of Leu-EK was less than 16% of that of Met-EK.
Positive_regulation (induced) of Met-EK associated with enkephalin
6) Confidence 0.46 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8278628 Disease Relevance 0.14 Pain Relevance 0.81
Myocardial ischemia enhanced the serum LDH, CK and CK-MB activities and caused premature beats.
Positive_regulation (enhanced) of CK-MB associated with heart rate under development, coronary artery disease and ischemia
7) Confidence 0.41 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 1.05 Pain Relevance 0.17
Adequate occlusion was confirmed by an elevation of plasma CK-MB levels four hours later or by a toluidine blue injection technique in rats which died earlier.
Positive_regulation (elevation) of CK-MB in plasma
8) Confidence 0.41 Published 1988 Journal Diabetes Res. Section Abstract Doc Link 3071443 Disease Relevance 0.67 Pain Relevance 0.10
Adequate occlusion was confirmed by an elevation of plasma CK-MB levels 4 h later or by a toluidine blue injection technique in rats which died earlier.
Positive_regulation (elevation) of CK-MB in plasma
9) Confidence 0.41 Published 1990 Journal Basic Res. Cardiol. Section Abstract Doc Link 2241770 Disease Relevance 0.78 Pain Relevance 0.56
TFR (20, 40 mg/kg) pretreatment decreased I/R-induced IS/AAR, markedly inhibited the increase of MDA content and the activity of CK and LDH, and also significantly inhibited the decline of NO content and the activity of NOS and SOD in serum.
Positive_regulation (increase) of CK associated with disorders of creatine metabolism
10) Confidence 0.36 Published 2008 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 18418440 Disease Relevance 0.60 Pain Relevance 0.10
Sixty minutes of left coronary artery occlusion and followed by 60 min of reperfusion caused a significant decrease in cardiac function and a significant increase in creatine kinase (CK) release and infarct size.
Positive_regulation (increase) of CK in left coronary artery
11) Confidence 0.35 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18166234 Disease Relevance 0.09 Pain Relevance 0.48
Our results showed that CK activity increased after acute exercise, with maximum activity after 1 h and remained elevated for at least 48 h.
Positive_regulation (increased) of CK
12) Confidence 0.35 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1192789 Disease Relevance 0.16 Pain Relevance 0.05
The increased CK and LDH reflects damages in myocardial cells peculiarly.
Positive_regulation (increased) of CK in myocardial cells
13) Confidence 0.32 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 1.07 Pain Relevance 0.24
Our study showed that diabetic cardiomyopathy may occur in untreated diabetic rats due to long standing hyperglycemia which was demonstrated by structural and functional changes such as increased CK activity and myocardial damage assessed by electron microscopic studies.
Positive_regulation (increased) of CK associated with hyperglycemia, diabetes mellitus and diabetic cardiomyopathies
14) Confidence 0.28 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 0.98 Pain Relevance 0.07
Serum creatine kinase (CK) activity and lactate level determinations
Positive_regulation (creatine) of CK
15) Confidence 0.25 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1192789 Disease Relevance 0 Pain Relevance 0
Reperfusion after 4 h of hypothermic ischemia caused a decline of cardiac function and an increase of creatine kinase (CK) release.
Positive_regulation (increase) of CK associated with ischemia
16) Confidence 0.24 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10100927 Disease Relevance 0.53 Pain Relevance 0.44
Serum creatine kinase (CK) activity increased in exercised rats.
Positive_regulation (increased) of CK
17) Confidence 0.24 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1192789 Disease Relevance 0 Pain Relevance 0
Our results showed that CK activity increased after acute exercise, with maximum activity after 1 h and remained elevated for at least 48 h.
Positive_regulation (elevated) of CK
18) Confidence 0.24 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1192789 Disease Relevance 0.17 Pain Relevance 0.05
Maximum CK activity was seen 1 h after acute exercise and remained elevated for up 48 h after exercise (Fig. 1).
Positive_regulation (elevated) of CK
19) Confidence 0.24 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1192789 Disease Relevance 0 Pain Relevance 0
The results showed that in both the thoracic and the lumber spinal cord, microinjection of 100 ng L-glutamate sodium into PVN could increase leucine-enkephalin (L-Ek), beta-endorphin (beta-Ep), dynorphinA(1-13) (DynA(1-13)) concentrations and PVN cauterization decreased L-Ek and beta-Ep concentrations.
Positive_regulation (increase) of L-Ek in PVN associated with glutamate, enkephalin and spinal cord
20) Confidence 0.22 Published 2009 Journal Peptides Section Abstract Doc Link 19452637 Disease Relevance 0.18 Pain Relevance 1.44

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