INT202620

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 2.63
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ppara, Rxra) DNA binding (Ppara, Rxra) lipid binding (Ppara)
enzyme binding (Rxra) transcription factor binding (Rxra) lipid metabolic process (Ppara)
Ppara (Mus musculus)
Rxra (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 219 98.12 Very High Very High Very High
agonist 454 95.60 Very High Very High Very High
Potency 5 93.80 High High
antagonist 37 90.56 High High
corticosteroid 3 77.92 Quite High
ischemia 9 62.92 Quite High
Central nervous system 106 54.88 Quite High
alcohol 16 52.32 Quite High
cINOD 15 51.60 Quite High
Peripheral nervous system 6 48.56 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 280 98.12 Very High Very High Very High
Obesity 127 88.64 High High
Frailty 22 87.80 High High
Brain Injury 59 83.00 Quite High
Liver Cancer 80 80.80 Quite High
Rheumatoid Arthritis 56 77.52 Quite High
Cicatrix 5 68.40 Quite High
Apoptosis 29 66.84 Quite High
Reperfusion Injury 7 63.76 Quite High
Cv Unclassified Under Development 7 62.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and PPAR, heterodimerize with retinoid X receptors (RXR) to form active transcription
PPAR Binding (heterodimerize) of RXR
1) Confidence 0.09 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.61 Pain Relevance 0.23
PPARs regulate gene transcription by heterodimerizing with the retinoid X receptor (RXR) and binding to specific consensus sequences (termed PPAR response elements, PPREs) in the enhancer regions of genes [6].
PPAR Binding (binding) of retinoid X receptor
2) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.08 Pain Relevance 0
PPARs regulate gene transcription by heterodimerizing with the retinoid X receptor (RXR) and binding to specific consensus sequences (termed PPAR response elements, PPREs) in the enhancer regions of genes [6].
PPAR Binding (binding) of RXR
3) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.08 Pain Relevance 0
heterodimerization with RXR, binding to DNA elements and PPAR?
PPAR Binding (heterodimerization) of RXR
4) Confidence 0.03 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.25 Pain Relevance 0.06
and its heterodimerizing partner RXR [Palmer et al., 1998], species differences in the promoter regions of PPAR?
PPAR Binding (heterodimerizing) of RXR
5) Confidence 0.03 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.28 Pain Relevance 0.05
and its heterodimerizing partner RXR [Palmer et al., 1998], species differences in the promoter regions of PPAR?
PPAR Binding (heterodimerizing) of RXR
6) Confidence 0.03 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.28 Pain Relevance 0.05
heterodimerization with RXR, binding to DNA elements and PPAR?
PPAR Binding (binding) of RXR
7) Confidence 0.03 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.25 Pain Relevance 0.06
heterodimerization with RXR, binding to DNA elements and PPAR?
PPAR Binding (heterodimerization) of RXR
8) Confidence 0.03 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.25 Pain Relevance 0.06
Like other nuclear receptors, each PPAR forms a heterodimer with RXR?
PPAR Binding (heterodimer) of RXR
9) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.05 Pain Relevance 0.09
retinoid X receptor (RXR), bind to PPAR response elements (PPREs)
PPAR Binding (bind) of RXR
10) Confidence 0.02 Published 2007 Journal PPAR Research Section Body Doc Link PMC1783742 Disease Relevance 0.14 Pain Relevance 0.10
retinoid X receptor (RXR), bind to PPAR response elements (PPREs)
PPAR Binding (bind) of retinoid X receptor
11) Confidence 0.02 Published 2007 Journal PPAR Research Section Body Doc Link PMC1783742 Disease Relevance 0.14 Pain Relevance 0.10
transrepression may also result from PPAR/RXR interaction with transcriptional
PPAR Binding (interaction) of RXR
12) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0 Pain Relevance 0.08
to occur through physical interaction between PPAR/RXR and other transcription
PPAR Binding (interaction) of RXR
13) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0.05 Pain Relevance 0.07
transrepression may also result from PPAR/RXR interaction with transcriptional
PPAR Binding (interaction) of RXR
14) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0 Pain Relevance 0.08
coactivator or corepressor molecules that are in limited supply, or PPAR/RXR interactions
PPAR Binding (interactions) of RXR
15) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0 Pain Relevance 0.08

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