INT202626

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.48
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fgfr2) Golgi apparatus (Fgfr2) plasma membrane (Fgfr2)
nucleus (Fgfr2) kinase activity (Fgfr2) cell-cell signaling (Fgfr2)
Anatomy Link Frequency
keratinocytes 4
Fgfr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 20 98.76 Very High Very High Very High
Inflammation 106 89.96 High High
psoriasis 4 70.72 Quite High
fibrosis 6 67.08 Quite High
cytokine 32 61.68 Quite High
member 8 8 57.04 Quite High
Inflammatory mediators 4 6.04 Low Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 118 98.76 Very High Very High Very High
Skin Diseases 20 98.72 Very High Very High Very High
Congenital Anomalies 41 97.40 Very High Very High Very High
Acanthosis 32 94.48 High High
Apoptosis 16 91.68 High High
Psoriasis 28 85.92 High High
Aging 16 84.88 Quite High
Dermatitis 24 80.88 Quite High
Alopecia 12 78.44 Quite High
Targeted Disruption 76 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was surprising because FGFs are potent mitogens for keratinocytes, and because epidermal hypotrophy was observed in the skin of newborn mice lacking FGFR2IIIb in all cells (Petiot et al., 2003) as well as in the skin of adult mice expressing a dominant-negative FGFR2IIIb mutant in keratinocytes (Werner et al., 1994).
Negative_regulation (lacking) of FGFR2IIIb in keratinocytes
1) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.49 Pain Relevance 0.08
These results demonstrate that the loss of FGFR1 and FGFR2 in keratinocytes initiates an inflammatory response.
Negative_regulation (loss) of FGFR2 in keratinocytes associated with inflammatory response
2) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.16 Pain Relevance 0.17
Generation and maintenance of mice lacking FGFR1 and/or FGFR2 in keratinocytes
Negative_regulation (lacking) of FGFR2 in keratinocytes
3) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.77 Pain Relevance 0.15
Loss of FGFR1 and FGFR2 in keratinocytes causes hyperproliferation in vivo but not in vitro
Negative_regulation (Loss) of FGFR2 in keratinocytes
4) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 1.06 Pain Relevance 0.03
The FGF pathway has been shown to regulate exocrine pancreatic development and our finding of down regulation of Fgfr2 is concordant with this [42,43].
Negative_regulation (regulation) of Fgfr2
5) Confidence 0.38 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox