INT202628

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 9.20
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Wnt1) extracellular space (Wnt1) extracellular region (Wnt1)
proteinaceous extracellular matrix (Wnt1) plasma membrane (Wnt1) cell-cell signaling (Wnt1)
Anatomy Link Frequency
embryos 5
epithelial cells 2
stomach 2
cranial nerves 1
posterior 1
Wnt1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 99.96 Very High Very High Very High
vagus nerve 11 94.92 High High
Inflammation 90 90.24 High High
cINOD 7 88.68 High High
Inflammatory response 15 85.64 High High
midbrain 22 79.04 Quite High
Dopamine 11 72.36 Quite High
Locus ceruleus 2 58.92 Quite High
Ventral tegmentum 1 50.68 Quite High
Raphe 16 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 343 100.00 Very High Very High Very High
Mesothelioma 79 100.00 Very High Very High Very High
Stomach Cancer 91 98.68 Very High Very High Very High
Apoptosis 233 95.80 Very High Very High Very High
Ventricular Heart Septal Defects 44 93.40 High High
INFLAMMATION 113 90.24 High High
Cancer 300 90.00 High High
Congenital Anomalies 80 89.20 High High
Cleft Palate 88 85.40 High High
Infection 45 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study shows that Spry1 expression in Wnt1-expressing neural crest cells in vivo results in facial clefting, cleft plate, failure of formation of the nasal and frontal bones as well as cardiovascular defects including ventricular septal defects, and outflow tract defects.
Gene_expression (expressing) of Wnt1 in nasal associated with ventricular heart septal defects
1) Confidence 0.67 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.79 Pain Relevance 0
Our data indicate that forced expression of Spry1 in Wnt1-Cre expressing cells results in reduced domains of Msx1 and Msx2 expression in craniofacial structures, while expression in the limb buds remains intact albeit at a reduced level.
Gene_expression (expressing) of Wnt1 in limb buds
2) Confidence 0.67 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.15 Pain Relevance 0
To determine the effect of conditional expression of Spry1 in Wnt1-Cre expressing cells on cranial nerve morphogenesis, E10.5 Spry1;Wnt1-Cre embryos were immunostained with a neurofilament-M antibody.
Gene_expression (expressing) of Wnt1 in embryos
3) Confidence 0.67 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.09 Pain Relevance 0.04
Forced expression of Spry1 in Wnt1-expressing cells was also associated with defects in the development of cranial nerves including the glossopharyngeal nerve (IX) and the vagus nerve (X).
Gene_expression (expressing) of Wnt1 in cranial nerves associated with vagus nerve
4) Confidence 0.67 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.37 Pain Relevance 0.05
Briefly, K19-Wnt1 mice express Wnt1, whereas K19-C2mE mice express COX-2 and mPGES-1 in gastric epithelial cells under transcriptional regulation by cytokeratin 19 (K19) gene promoter.
Gene_expression (express) of Wnt1 in epithelial cells
5) Confidence 0.67 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.85 Pain Relevance 0.13
Our previous studies have shown that the flanked Lmx1b allele was deleted in Wnt1-Cre; Lmx1bflox/?
Gene_expression (/) of Wnt1
6) Confidence 0.65 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.15
The Wnt/?
Gene_expression (/) of Wnt
7) Confidence 0.65 Published 2007 Journal Yale J Biol Med Section Body Doc Link PMC1994795 Disease Relevance 0.90 Pain Relevance 0.08
For example, significant differences in expression of FGF, wnt and LIF pathway genes are observed between human neural stem cells derived from hES cells and fetal neural stem cells [45].
Gene_expression (expression) of wnt in neural
8) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
In addition, the branchial arches of Spry1;R26R:Wnt1-Cre embryos were smaller than that of the R26R;Wnt1-Cre control embryos, however ?
Gene_expression (branchial arches) of Wnt1 in embryos
9) Confidence 0.58 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.22 Pain Relevance 0
To over express Spry1 in neural crest cells CAGGFP-Spry1 mice were crossed with Wnt1-Cre mice, and double transgenic mice were identified by PCR of genomic DNA from either tails or placenta using specific primer for GFP and Cre.
Gene_expression (crossed) of Wnt1 in neural crest cells associated with targeted disruption
10) Confidence 0.58 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.42 Pain Relevance 0
In addition, the branchial arches of Spry1;R26R:Wnt1-Cre embryos were smaller than that of the R26R;Wnt1-Cre control embryos, however ?
Gene_expression (branchial arches) of Wnt1 in embryos
11) Confidence 0.58 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.21 Pain Relevance 0
In Spry1;R26R;Wnt1-Cre transgenic embryos ?
Gene_expression (embryos) of Wnt1 in embryos associated with targeted disruption
12) Confidence 0.58 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.52 Pain Relevance 0
-gal staining (Figure 4A-D) and sections (Figure 4E-H) through E10.5 Spry1;R26R;Wnt1-Cre embryos revealed ?
Gene_expression (staining) of Wnt1 in embryos
13) Confidence 0.58 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.18 Pain Relevance 0
Briefly, K19-Wnt1 mice express Wnt1, whereas K19-C2mE mice express COX-2 and mPGES-1 in gastric epithelial cells under transcriptional regulation by cytokeratin 19 (K19) gene promoter.
Gene_expression (express) of Wnt1 in epithelial cells
14) Confidence 0.58 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.86 Pain Relevance 0.13
Consistent with this, over expression of Wnt1 using the Pdx1 promoter causes a phenotype suggesting a posterior transformation of the proximal foregut [41].
Gene_expression (expression) of Wnt1 in posterior
15) Confidence 0.56 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0 Pain Relevance 0
Forced expression of Spry1 in Wnt1-Cre expressing cells resulted craniofacial and cardiac defects.
Gene_expression (expressing) of Wnt1
16) Confidence 0.52 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.30 Pain Relevance 0.03
K19-Wnt1 transgenic mice expressing Wnt1 in the gastric epithelial cells develop sporadic dysplastic lesions in the glandular stomach (Oshima et al, 2006).
Gene_expression (expressing) of Wnt1 in stomach associated with targeted disruption
17) Confidence 0.52 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.96 Pain Relevance 0.09
K19-Wnt1 transgenic mice expressing Wnt1 in the gastric epithelial cells develop sporadic dysplastic lesions in the glandular stomach (Oshima et al, 2006).
Gene_expression (expressing) of Wnt1 in stomach associated with targeted disruption
18) Confidence 0.45 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.95 Pain Relevance 0.09
Our study shows that Spry1 expression in Wnt1-expressing neural crest cells in vivo results in facial clefting, cleft plate, failure of formation of the nasal and frontal bones as well as cardiovascular defects including ventricular septal defects, and outflow tract defects.
Gene_expression (expressing) of Wnt1 in frontal bones associated with ventricular heart septal defects
19) Confidence 0.23 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.79 Pain Relevance 0
MM cell cultures expressed high mRNA levels of the mesothelioma markers mesothelin (MSLN), calretinin (CALB2), the WNT1 antagonist DKK1 and the stem cell marker BMI-1.
Gene_expression (expressed) of WNT1 in stem cell associated with mesothelioma and antagonist
20) Confidence 0.19 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2850899 Disease Relevance 0.65 Pain Relevance 0.05

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