INT202629

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 4.09
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pdx1) nucleus (Pdx1) DNA binding (Pdx1)
transcription factor binding (Pdx1) cytoplasm (Pdx1)
Anatomy Link Frequency
liver 2
blood 1
pancreas 1
gut epithelium 1
Pdx1 (Mus musculus)
Pain Link Frequency Relevance Heat
diabetic neuropathy 2 77.12 Quite High
Inflammation 17 74.48 Quite High
Inflammatory response 2 32.08 Quite Low
fibrosis 12 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
Chronic pancreatitis 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 46 100.00 Very High Very High Very High
Targeted Disruption 121 99.24 Very High Very High Very High
Fibrosarcoma 4 98.76 Very High Very High Very High
Diabetes Mellitus 282 98.56 Very High Very High Very High
Hyperglycemia 21 98.08 Very High Very High Very High
Pancreatitis 24 96.84 Very High Very High Very High
Congenital Anomalies 7 96.28 Very High Very High Very High
Hyperplasia 6 78.72 Quite High
Diabetic Neuropathy 2 77.12 Quite High
Lifespan 6 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, Heiser et al. found that two different Pdx1-cre strains caused significantly divergent phenotypes when bred to transgenic mice harboring an allele of ?
Gene_expression (caused) of Pdx1 associated with targeted disruption and sprains and strains
1) Confidence 0.60 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0.67 Pain Relevance 0
This homeotic transcription factor is normally expressed the gut epithelium anterior to the Pdx1 domain and its misexpression in the pancreas suggests that these cells may have undergone some degree of homeotic transformation to an anterior fate [40 and Anne Grapin-Botton, personal communication].
Gene_expression (expressed) of Pdx1 in gut epithelium
2) Confidence 0.60 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0 Pain Relevance 0
GeneChip and QPCR were congruent with our immunostaining findings as Pdx1 transcript levels did not differ between wildtype and ?
Gene_expression (levels) of Pdx1
3) Confidence 0.60 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0 Pain Relevance 0
-catenin influenced the development of pancreatic progenitors expressing Pdx1.
Gene_expression (expressing) of Pdx1
4) Confidence 0.54 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0.06 Pain Relevance 0
We analyzed pancreata at E12.5 and found no difference in the number of cells expressing Pdx1 in the ?
Gene_expression (expressing) of Pdx1
5) Confidence 0.54 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0.11 Pain Relevance 0
-catenin alleles in the pancreas [Pdx1-cre floxed ?
Gene_expression (alleles) of Pdx1 in pancreas
6) Confidence 0.53 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0.53 Pain Relevance 0
Forced expression of Pdx-1 [38], MafA [39], or GLP-1 [40] in intestinal epithelia by adenovirus-mediated gene transfer induced the expression of insulin and lowered blood glucose levels in streptozotocin-induced diabetic animals.
Gene_expression (expression) of Pdx-1 in blood associated with diabetes mellitus
7) Confidence 0.28 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883354 Disease Relevance 0.53 Pain Relevance 0
An exciting report demonstrated that expressing a specific combination of three transcription factors, Pdx-1, Ngn3, and musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), resulted in amelioration of hyperglycemia.
Gene_expression (expressing) of Pdx-1 associated with hyperglycemia and fibrosarcoma
8) Confidence 0.28 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883354 Disease Relevance 0.49 Pain Relevance 0
Systemic delivery of Pdx-1 carrying the VP16 transcriptional activation domain (Pdx-1/VP16) or Ngn-3 and BTC gene resulted in insulin production in liver [36,37].
Gene_expression (carrying) of Pdx-1 in liver
9) Confidence 0.24 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883354 Disease Relevance 0.38 Pain Relevance 0
Systemic delivery of Pdx-1 carrying the VP16 transcriptional activation domain (Pdx-1/VP16) or Ngn-3 and BTC gene resulted in insulin production in liver [36,37].
Gene_expression (carrying) of Pdx-1 in liver
10) Confidence 0.11 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883354 Disease Relevance 0.39 Pain Relevance 0
B-inducing kinase and RELB can lead to increased PDX-1 and insulin production independent of changes in cell turnover [91].
Gene_expression (production) of PDX-1
11) Confidence 0.05 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.93 Pain Relevance 0.08

General Comments

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