INT202633

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.85
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Wnt1) extracellular space (Wnt1) extracellular region (Wnt1)
proteinaceous extracellular matrix (Wnt1) plasma membrane (Wnt1) cell-cell signaling (Wnt1)
Anatomy Link Frequency
embryos 4
posterior 4
limb buds 2
Wnt1 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
vagus nerve 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 121 100.00 Very High Very High Very High
Apoptosis 73 95.80 Very High Very High Very High
Congenital Anomalies 23 75.96 Quite High
Persistent Truncus Arteriosus 12 62.52 Quite High
Death 7 25.76 Quite Low
Cancer 4 13.52 Low Low
Sprains And Strains 17 12.80 Low Low
Cleft Palate 24 5.00 Very Low Very Low Very Low
Pancreatic Cancer 12 5.00 Very Low Very Low Very Low
Ventricular Heart Septal Defects 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-gal staining (Figure 4A-D) and sections (Figure 4E-H) through E10.5 Spry1;R26R;Wnt1-Cre embryos revealed ?
Positive_regulation (through) of Gene_expression (staining) of Wnt1 in embryos
1) Confidence 0.43 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.18 Pain Relevance 0
In Spry1;R26R;Wnt1-Cre transgenic embryos ?
Positive_regulation (-) of Gene_expression (embryos) of Wnt1 in embryos associated with targeted disruption
2) Confidence 0.43 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.52 Pain Relevance 0
Our data indicate that forced expression of Spry1 in Wnt1-Cre expressing cells results in reduced domains of Msx1 and Msx2 expression in craniofacial structures, while expression in the limb buds remains intact albeit at a reduced level.
Positive_regulation (forced) of Gene_expression (expressing) of Wnt1 in limb buds
3) Confidence 0.43 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.15 Pain Relevance 0
Consistent with this, over expression of Wnt1 using the Pdx1 promoter causes a phenotype suggesting a posterior transformation of the proximal foregut [41].
Positive_regulation (causes) of Gene_expression (expression) of Wnt1 in posterior
4) Confidence 0.42 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0 Pain Relevance 0
Consistent with this, over expression of Wnt1 using the Pdx1 promoter causes a phenotype suggesting a posterior transformation of the proximal foregut [41].
Positive_regulation (using) of Gene_expression (expression) of Wnt1 in posterior
5) Confidence 0.42 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0 Pain Relevance 0

General Comments

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