INT20264

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Context Info
Confidence 0.46
First Reported 1990
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 13.14
Pain Relevance 13.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Chkb)
Anatomy Link Frequency
PVH 2
teeth 1
PGE2 1
lung 1
incisor 1
Chkb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 84 100.00 Very High Very High Very High
Central grey 42 100.00 Very High Very High Very High
antagonist 26 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
Acupuncture 10 99.84 Very High Very High Very High
Pain 122 99.74 Very High Very High Very High
Pain threshold 11 99.62 Very High Very High Very High
Inflammation 82 99.24 Very High Very High Very High
bradykinin 24 99.22 Very High Very High Very High
analgesia 29 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 42 100.00 Very High Very High Very High
Pain 171 99.74 Very High Very High Very High
INFLAMMATION 93 99.24 Very High Very High Very High
Arrhythmias 2 Under Development 3 99.12 Very High Very High Very High
Death 16 99.08 Very High Very High Very High
Diabetes Mellitus 61 99.06 Very High Very High Very High
Heart Rate Under Development 10 98.74 Very High Very High Very High
Cv General 2 Under Development 7 98.24 Very High Very High Very High
Myocardial Infarction 51 96.92 Very High Very High Very High
Cleidocranial Dysplasia 116 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE2, like hydrocortisone and lidocaine, inhibited the BANA-degrading activity, in a dose-dependent manner, regardless of the presence or absence of BK, as well as resulted in a decrease of EK production in the pulp.
Gene_expression (production) of EK in PGE2 associated with enkephalin, bradykinin and lidocaine
1) Confidence 0.46 Published 1990 Journal Osaka Daigaku Shigaku Zasshi Section Abstract Doc Link 2135403 Disease Relevance 0.06 Pain Relevance 0.83
On the other hand, it has recently been known that BK showed an indirect activating effect on cathepsin B, a lysosomal enzyme, which may be mediated through calcium ion-dependent steps, followed by production of enkephalins (EK), endogenous anti-inflammatory and analgesic peptides, in the rat incisor pulp.
Gene_expression (production) of EK in incisor associated with inflammation, analgesic, enkephalin and bradykinin
2) Confidence 0.40 Published 1990 Journal Osaka Daigaku Shigaku Zasshi Section Abstract Doc Link 2135403 Disease Relevance 0.19 Pain Relevance 0.77
For the determination of CK levels the rats were sacrificed immediately or 1 h, 6 h and 48 h after exercise.
Gene_expression (levels) of CK
3) Confidence 0.34 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1192789 Disease Relevance 0 Pain Relevance 0
The serum CK activity was determined by a colorimetric assay (CK-NAC kit, Bayer), at 340 nm, and was expressed in U/L, where 1 U resulted in the phoshorylation of 1 mmol of creatine per min at 25°C.
Gene_expression (expressed) of CK
4) Confidence 0.34 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1192789 Disease Relevance 0 Pain Relevance 0
Our study found that the increased ratios of S/L, LDH and CK, and the decreased levels of TP in groups M, C and group K compared to group S in the survival rats.
Gene_expression (ratios) of CK
5) Confidence 0.31 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 1.24 Pain Relevance 0.25
In control teeth at this age, the periphery of the coronal dental pulp showed intense ALP-positive and HSP-25-positive reactions, whereas there were no TRAP-positive or CK-positive cells.
Neg (no) Gene_expression (positive) of CK in teeth
6) Confidence 0.25 Published 2006 Journal Cell Tissue Res. Section Abstract Doc Link 16596394 Disease Relevance 0.15 Pain Relevance 0.09
Some proliferated cells in these lesions had abundant cytoplasm and usually expressed CK abundantly; electron microscopy showed that most of these cells had lamellar body-like structures.
Gene_expression (expressed) of CK in body
7) Confidence 0.24 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.59 Pain Relevance 0.04
In the thickened alveolar septa, some cells expressed both CK and PCNA (Fig. 3A, B).
Gene_expression (expressed) of CK
8) Confidence 0.24 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.37 Pain Relevance 0
In order to determine the origin of the proliferated cells, we studied CK and S-100 expression in lung specimens.
Gene_expression (expression) of CK in lung
9) Confidence 0.21 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.41 Pain Relevance 0
CK was positive in some proliferated cells, but S-100 was negative.
Gene_expression (positive) of CK
10) Confidence 0.18 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.40 Pain Relevance 0
Radioimmunoassy results showed that AVP increased leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek), beta-endorphin (beta-Ep) rather than dynorphin A(1-13) (DynA(1-13)) concentrations in PAG slice culture liquid, and V(2) receptor antagonist: d(CH(2))(5)[D-Ile(2), Ile(4), Ala(9)-NH(2)]AVP decreased L-Ek, M-Ek and beta-Ep, not DynA(1-13) concentrations in PAG slice culture liquid in a dose-dependent manner, but V(1) receptor antagonist: d(CH(2))(5)Tyr(Me)AVP did not change these peptide concentrations in PAG slice culture liquid.
Gene_expression (antagonist) of L-Ek associated with dynorphin, antagonist, enkephalin and central grey
11) Confidence 0.14 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113946 Disease Relevance 0.75 Pain Relevance 1.44
Radioimmunoassy results showed that AVP increased leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek), beta-endorphin (beta-Ep) rather than dynorphin A(1-13) (DynA(1-13)) concentrations in PAG slice culture liquid, and V(2) receptor antagonist: d(CH(2))(5)[D-Ile(2), Ile(4), Ala(9)-NH(2)]AVP decreased L-Ek, M-Ek and beta-Ep, not DynA(1-13) concentrations in PAG slice culture liquid in a dose-dependent manner, but V(1) receptor antagonist: d(CH(2))(5)Tyr(Me)AVP did not change these peptide concentrations in PAG slice culture liquid.
Gene_expression ([D-Ile) of L-Ek associated with dynorphin, antagonist, enkephalin and central grey
12) Confidence 0.14 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113946 Disease Relevance 0.76 Pain Relevance 1.44
The results showed that AVP elevated the concentrations of leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), but did not change the concentrations of dynorphinA(1-13) (DynA(1-13)), OXT, classical neurotransmitters including achetylcholine (Ach), choline (Ch), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), dopamine (DA), norepinephrine (NE) and epinephrine (E), and their metabolic products in PAG perfusion liquid.
Gene_expression (concentrations) of L-Ek associated with dopamine, glutamate, gaba, neurotransmitter, enkephalin, central grey and serotonin
13) Confidence 0.13 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17341433 Disease Relevance 0.75 Pain Relevance 1.51
The results showed that AVP elevated the concentrations of leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), but did not change the concentrations of dynorphinA(1-13) (DynA(1-13)), OXT, classical neurotransmitters including achetylcholine (Ach), choline (Ch), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), dopamine (DA), norepinephrine (NE) and epinephrine (E), and their metabolic products in PAG perfusion liquid.
Gene_expression (concentrations) of M-Ek associated with dopamine, glutamate, gaba, neurotransmitter, enkephalin, central grey and serotonin
14) Confidence 0.11 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17341433 Disease Relevance 0.81 Pain Relevance 1.55
The effect of acupuncture on the concentrations of arginine vasopressin (AVP), oxytocin (OXT), leucine-enkephaline (L-Ek), beta-endorphin (beta-Ep) and dynorphinA(1-13) (DynA(1-13)) was investigated in rat PVH.
Spec (investigated) Gene_expression (concentrations) of L-Ek in PVH associated with acupuncture
15) Confidence 0.10 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16459202 Disease Relevance 0.07 Pain Relevance 0.60
The results showed that electrical stimulation of the PVN increased the pain threshold, and L-glutamate sodium injection into the PVN elevated the pain threshold, but the PVN cauterization decreased the pain threshold; pain stimulation raised the arginine vasopressin (AVP), not oxytocin (OXT), leucine-enkephalin (L-Ek), beta-endorphin (beta-Ep) and DynorphinA1-13 (DynA1-13) concentrations in the PVN tissue using micropunch method, heightened AVP, L-Ek, beta-Ep and DynA1-13, not OXT concentrations in the PVN perfuse liquid, and reduced the number of AVP-, not OXT, L-Ek, beta-Ep and DynA1-13-immunoreactive neurons in the PVN especially in the posterior magnocellular part of the PVN using immunocytochemistry.
Gene_expression (raised) of L-Ek in PVN associated with pain, glutamate, pain threshold and enkephalin
16) Confidence 0.10 Published 2006 Journal Brain Res. Section Abstract Doc Link 16409991 Disease Relevance 0.54 Pain Relevance 1.42
In the group treated with 8 and 16 pulses, no alteration in LV function was observed; transient asystole and reduced contractile function as well as slightly elevated levels of TNT and CK-MB were observed only when 32 pulses were administered.
Gene_expression (levels) of CK-MB associated with heart rate under development
17) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012686 Disease Relevance 0.28 Pain Relevance 0.05
Although the CK elevations may occur at any time during therapy, the greatest incidence of CK elevation was during the first two months of treatment.35 Elevated CKs were more often seen in males, in patients who were being treated with anti-depressants or antiepileptics, and in patients treated with IT morphine.35 The majority of patients with elevations in CK, even for prolonged periods of time, did not experience limiting side effects.
Gene_expression (elevations) of CK associated with morphine and intrathecal
18) Confidence 0.09 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710384 Disease Relevance 0.43 Pain Relevance 0.51
Although the CK elevations may occur at any time during therapy, the greatest incidence of CK elevation was during the first two months of treatment.35 Elevated CKs were more often seen in males, in patients who were being treated with anti-depressants or antiepileptics, and in patients treated with IT morphine.35 The majority of patients with elevations in CK, even for prolonged periods of time, did not experience limiting side effects.
Gene_expression (elevation) of CK associated with morphine and intrathecal
19) Confidence 0.09 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710384 Disease Relevance 0.39 Pain Relevance 0.49
Troponin as well as CK-MB levels were not elevated in any of the samples tested.
Gene_expression (levels) of CK-MB
20) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475607 Disease Relevance 0.32 Pain Relevance 0

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