INT202645

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.05
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hoxb4) nucleus (Hoxb4) DNA binding (Hoxb4)
Anatomy Link Frequency
embryos 1
neurons 1
hindbrain 1
Hoxb4 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 18 81.84 Quite High
dorsal root ganglion 5 37.44 Quite Low
Pain 11 5.00 Very Low Very Low Very Low
Spinal cord 9 5.00 Very Low Very Low Very Low
medulla 9 5.00 Very Low Very Low Very Low
vagus nerve 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 8 51.08 Quite High
Nervous System Malformation 30 50.00 Quite Low
Death 8 40.96 Quite Low
Ganglion Cysts 17 36.48 Quite Low
Congenital Anomalies 25 34.52 Quite Low
Nociception 8 28.32 Quite Low
Neuroblastoma 40 5.00 Very Low Very Low Very Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 18 5.00 Very Low Very Low Very Low
Sprains And Strains 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have found that at E16.5, there is a substantial increase in the expression of Hoxb4 in the ?
Gene_expression (expression) of Hoxb4
1) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0.05 Pain Relevance 0
Hoxb4 is expressed caudal to r6/7, serving as a useful marker for caudal hindbrain development [40].
Gene_expression (expressed) of Hoxb4 in hindbrain
2) Confidence 0.66 Published 2010 Journal Neural Dev Section Body Doc Link PMC2843687 Disease Relevance 0 Pain Relevance 0
No difference in the staining pattern of Hoxa3, Hoxb3, and Hoxb4 was detected between wild type and homozygote mutants (Figure 6C-F and data not shown).
Gene_expression (pattern) of Hoxb4
3) Confidence 0.51 Published 2010 Journal Neural Dev Section Body Doc Link PMC2843687 Disease Relevance 0 Pain Relevance 0
In order to determine whether an alteration in early hindbrain development might contribute to the CN defects observed in Nav2-/- hypomorphic embryos, the expression of KROX20 (EGR2) protein, and Hoxa3, Hoxb3, and Hoxb4 mRNAs were studied.
Gene_expression (expression) of Hoxb4 in embryos
4) Confidence 0.23 Published 2010 Journal Neural Dev Section Body Doc Link PMC2843687 Disease Relevance 0 Pain Relevance 0
In addition, most c-ret and isolectin B4+ neurons also expressed Dok4 (Figure 5A–D).
Gene_expression (neurons) of isolectin B4 in neurons
5) Confidence 0.01 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.13

General Comments

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